Aidan I. Brown

This study uses APEX-seq to show that mitochondrial mRNA localization and local translation are kinetically controlled by retrograde dynein transport and translation efficiency.

The paper models how spatially localized ligand binding to receptors affects signaling response consistency, ligand requirements, and response timing compared to uniform binding.

The paper identifies mitochondrial pull-outs as a new type of dynamic tubulation regulated by mitochondrial activity and metabolism, enhancing network connectivity and respiratory function.

The paper models how mitochondrial network structure and dynamics affect protein spread, finding that branching networks enable faster spread with slower dynamics.

This study shows that mitochondrial fragmentation increases protein expression noise due to stochastic co-translational targeting, and that fission-fusion processes reduce this heterogeneity.