Yuanzhong Pan

This paper evaluates cross-talk between fluorescent proteins and NADH FLIM, identifying compatible FPs and providing a pipeline to manage cross-excitation in metabolic imaging.

This paper uses machine learning to infer neuroblastoma cell states from morphology without transcriptomics, showing alignment with scRNA-seq and tracking state transitions.

This study identifies a YAP-PIEZO1 signaling axis that links extracellular matrix density to invasion in fusion-negative rhabdomyosarcoma, with therapeutic implications.

This study shows that ECM topography promotes adrenergic to mesenchymal transition in neuroblastoma by enhancing cell-ECM interactions and activating the Rho-associated kinase pathway.

This study identifies differences in cell-ECM interaction between rhabdomyosarcoma subtypes, showing FNRMS has heightened interaction regulated by TGFβ signaling, while PAX3-FOXO1 in FPRMS suppresses this interaction.

This paper introduces a gel-top culture model that replicates mesenchymal features of glioblastoma cells and identifies CK2 as a potential therapeutic target.

This paper identifies a cis-regulatory mechanism in triple-negative breast cancer where targeting circadian transcription factors with small molecules represses a circadian transcriptional program, offering a new therapeutic strategy.