Antonios Chronopoulos

This study shows engineered extracellular vesicles delivering BACE1-targeting siRNA reduce amyloid beta plaques in a mouse model of Alzheimer's disease.

This study identifies HA and CD44 as mediators of matrix changes and fibrosis in PSC, showing their targeting can reverse disease progression.

This study shows that ECM topography promotes adrenergic to mesenchymal transition in neuroblastoma by enhancing cell-ECM interactions and activating the Rho-associated kinase pathway.

This study identifies differences in cell-ECM interaction between rhabdomyosarcoma subtypes, showing FNRMS has heightened interaction regulated by TGFβ signaling, while PAX3-FOXO1 in FPRMS suppresses this interaction.