Shaun W. Jackson

This study shows that CD19 CAR-engineered regulatory T cells reduce B cell numbers, inflammation, and autoantibodies in lupus models, promoting long-term immune tolerance.

This study shows autoreactive B cells can initiate spontaneous germinal centers and autoimmunity through antibody-dependent mechanisms, independent of T cell interactions or antigen presentation.

This study uses single-cell RNA-sequencing and spatial transcriptomics to analyze myeloid cell dynamics in lupus nephritis, showing shifts in immune responses linked to disease progression.

This study uses single cell spatial transcriptomics to analyze kidney tissue from childhood-onset lupus nephritis patients, revealing spatial interactions between immune cells and kidney stroma.

Insitutype types cells in spatial transcriptomics with a likelihood model over every expression value, admits image and neighbourhood priors, and is reported to cluster millions of cells quickly.