Author

Harini Krishnan

National Centre for Biological SciencesORCID 0000-0002-7079-9909Unclaimed ORCID profile · follow to get notified of new preprints

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5 shared papersNeuroscience

Padinjat RaghuORCID

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5 papers

Recent·Most cited

BiochemistryJournal of Cell SciencePeer-reviewedJun 16, 2025

The conserved biochemical activity and function of an early metazoan phosphatidylinositol 5 phosphate 4-kinase regulates growth and development.

Harini Krishnan, Suhail Muzaffar, Sanjeev Sharma…·Padinjat Raghu

This study identifies PIP4K as a conserved enzyme in early metazoans that regulates growth and development through insulin receptor signaling.

5 citations

mouseDrosophila

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Cell BiologyThe Journal of Cell BiologyPeer-reviewedJan 30, 2025

Ca2+ binding to Esyt is required to modulate membrane contact site density in Drosophila photoreceptors

Vaisaly R Nath, Harini Krishnan, Shirish Mishra, Padinjat Raghu

This study shows that Ca2+ binding to dEsyt modulates ER-PM MCS density in Drosophila photoreceptors, linking Ca2+ influx to signal transduction.

4 citations

Drosophilaproteomics

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NeurosciencebioRxivPreprintJul 28, 2023

A genetic screen to uncover molecular mechanisms underlying lipid transfer protein function at membrane contact sites and neurodegeneration.

Shirish Mishra, Vaishnavi Manohar, Shabnam Chandel…·Padinjat Raghu

This study identifies suppressors of RDGB function in Drosophila and links them to novel lipids and ubiquitination processes in retinal degeneration and neurodevelopmental diseases.

DOI 10.1101/2023.07.28.550979

Drosophilaexperimental assay

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NeurosciencebioRxivPreprintOct 14, 2022

IMPA1 dependent regulation of plasma membrane phosphatidylinositol 4,5-bisphosphate turnover and calcium signalling by lithium

Sankhanil Saha, Harini Krishnan, Padinjat Raghu

This study shows lithium inhibits IMPA1, reducing PIP2 resynthesis and calcium signaling in neural cells, leading to decreased neuronal excitability.

2 citations

humanbulk RNA-seq

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GenomicsbioRxivPreprintJun 22, 2021

Genomic sequencing of Lowe syndrome trios reveal a mechanism for the heterogeneity of neurodevelopmental phenotypes

Husayn Ahmed Pallikonda, Pramod Kumar Singh, Rajan S. Thakur…·Padinjat Raghu

The paper identifies genetic variants contributing to clinical heterogeneity in Lowe syndrome by analyzing genomic data from affected family members.

4 citations

humanwhole-exome sequencing

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