Author

Karel Olavarría

Delft University of TechnologyORCID 0000-0003-0435-7640Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Mark C.M. van LoosdrechtiD· 2 shared Ben Abbas· 1 shared DaeHyun Daniel Kim· 1 shared Daniel C. VolkeiD· 1 shared David Gregory WeissbrodtiD· 1 shared Enzo KingmaiD· 1 shared Francesc Corbera-RubioiD· 1 shared Joana Castro Gomes· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersSystems Biology

Mark C.M. van LoosdrechtORCID

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4 papers

Recent·Most cited

Evolutionary BiologyEMBO ReportsPeer-reviewedFeb 16, 2026

Global genetic rewiring during compensatory evolution in the yeast polarity network

Enzo Kingma, Marieke M. Glazenburg, Karel Olavarría, Liedewij Laan

This study shows that compensatory mutations in yeast rewiring gene fitness across cellular processes, not just individual genes, highlighting the role of functional overlap and network interconnectedness.

4 citations

yeastexperimental assay

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Systems BiologyISME CommunicationsPeer-reviewedJan 1, 2025

Selective enrichment of high-affinity clade II N2O-reducers in a mixed culture

Michele Laureni, Francesc Corbera-Rubio, DaeHyun Daniel Kim…·Mark C.M. van Loosdrecht

The paper shows clade II N2O-reducers outcompete clade I under low N2O availability, and coexist under high N2O, with cobalamin interactions influencing community composition.

11 citations

metagenomicsexperimental assay

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Systems BiologymSystemsPeer-reviewedMar 15, 2021

Cofactor specificity of glucose-6-phosphate dehydrogenase isozymes in Pseudomonas putida reveals a general principle underlying glycolytic strategies in bacteria

Daniel C. Volke, Karel Olavarría, Pablo I. Nikel

The paper analyzes G6PDH isozymes in Pseudomonas putida to show how cofactor specificity and gene duplication contribute to redox balance and metabolic strategies in bacteria.

47 citations

bacteria (other)statistical model

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MicrobiologybioRxivPreprintMar 11, 2019

Revealing metabolic flexibility of Candidatus Accumulibacter phosphatis through redox cofactor analysis and metabolic network modeling

Leonor Guedes da Silva, Karel Olavarria Gamez, Joana Castro Gomes…·Sebastian Aljoscha Wahl

This study uses metabolic network modeling and enzyme assays to reveal that Candidatus Accumulibacter phosphatis preferentially uses NADH for PHA production, enhancing metabolic flexibility in EBPR systems.

DOI 10.1101/458331

bacteria (other)metabolomics

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