David A. Christian

This study investigates the role of integrins in T cell trafficking and resistance to Cryptosporidium parvum, finding that integrin L is critical for T cell-mediated control of infection while 4β7 is not essential.

This study shows that IL-27 limits HSPC differentiation during infection and prevents stem cell exhaustion by reducing monocyte production and maintaining HSPC function.

This study shows that adding IL-12 mRNA-LNPs to an mRNA vaccine enhances CD8+ T cell responses against model antigens and improves protection against infections and tumors.

The paper develops the STORE.2 model to simulate CD8+ T cell proliferation and response to antigen presentation, showing its accuracy in vitro and in vivo.

This study shows immune pressure targets Toxoplasma gondii bradyzoites, which mitigate tissue damage and promote host-parasite survival.

This study shows that IL-27, induced by mRNA-LNP vaccines, enhances CD8+ T cell responses through type I IFN signaling, improving vaccine efficacy against pathogens and tumors.

Subunit vaccines induce CD8+ T cells with memory fate characteristics that maintain proliferative capacity via IL-27 receptor signaling during expansion.

The paper investigates the role of intestinal cDC1s in CD4+ T cell-mediated resistance to Cryptosporidium, showing they support T cell expansion and effector function through IL-12-dependent and -independent mechanisms.