Ian S. Cohn

The paper creates a single-cell and spatial transcriptomics atlas of the ileum during diverse infections, revealing novel cell states and immune responses.

This study investigates the role of integrins in T cell trafficking and resistance to Cryptosporidium parvum, finding that integrin L is critical for T cell-mediated control of infection while 4β7 is not essential.

This study uses single-cell RNA sequencing to analyze how intestinal epithelial cells respond to Cryptosporidium infection and IFN-gamma, showing delayed parasite reduction with cytokine treatment.

The paper investigates the role of intestinal cDC1s in CD4+ T cell-mediated resistance to Cryptosporidium, showing they support T cell expansion and effector function through IL-12-dependent and -independent mechanisms.