Stefan A. Koestler

This study identifies USP50 as a ubiquitin-binding protein that regulates helicase and nuclease activities during DNA replication to prevent fork collapse and maintain genomic stability.

The paper uses super-resolution microscopy to study histone modifications in Drosophila Y loops, revealing exclusivity of modifications at the chromatin cluster level and their association with transcriptional activity.

This study uses super-resolution microscopy to analyze the structure of transcriptionally active chromatin loops in Drosophila primary spermatocytes, revealing their organization into nucleosome clusters and RNA polymerase foci.