Ryan D. Pardy

This study shows that IL-27 limits HSPC differentiation during infection and prevents stem cell exhaustion by reducing monocyte production and maintaining HSPC function.

This study shows that type 1 immunity, via IFNγ signaling, protects intestinal tissue from damage during helminth infection without reducing parasite burden.

This study uses single-cell RNA sequencing to analyze how intestinal epithelial cells respond to Cryptosporidium infection and IFN-gamma, showing delayed parasite reduction with cytokine treatment.

The paper investigates the role of intestinal cDC1s in CD4+ T cell-mediated resistance to Cryptosporidium, showing they support T cell expansion and effector function through IL-12-dependent and -independent mechanisms.