Matthew A. Ciorba

This study develops mouse models of perianal fistulizing Crohn's disease and identifies IFN-gamma signaling as a therapeutic target.

This study shows that locally produced complement factor B in the gut reduces colitis, highlighting its role in mucosal immunity.

This paper identifies rs1077773 as a pharmacogenomic eQTL for AHR activity, showing it enhances transcriptional activity in organoids and reduces inflammatory cytokine production in macrophages.

This paper develops an in vitro model of the human intestinal epithelium that closely mimics in vivo cell types using single-cell transcriptomics and a biomedical foundation model.

This study develops patient-derived tumor organoids from non-metastatic NSCLC tumors to test drug responses and identify chemoresistance mechanisms, finding 50% of organoids were chemo-resistant and could be sensitized by repurposed drugs.