Wanyu Li

This study determines cryo-EM structures of orthoflaviviruses bound to LDLR family receptors, revealing distinct binding modes and receptor engagement mechanisms.

The paper uses a pro-apoptotic CRISPR screening strategy in mosquito cells to identify Lachesin as a critical CHIKV entry factor.

This study identifies the molecular basis of chikungunya virus recognition of the mosquito-specific receptor Lachesin using cryo-EM structures and shows a Lachesin polymorphism that blocks virus entry.

This study identifies Lachesin as a mosquito receptor for multiple arthritogenic alphaviruses using CRISPR screening in Aedes albopictus cells.

The paper identifies the HUSH complex as a regulator of EBV-transformed B cell sensitivity to NK cell surveillance by repressing the NKG2A ligand γ-protocadherin.

This paper identifies GBP5 as an ISG that inhibits viral replication by blocking N-glycosylation of viral proteins, including SARS-CoV-2 spike, through interaction with the OST complex.

The paper identifies receptor-binding polymorphisms in WEEV that explain shifts in receptor dependencies and enable nonpathogenic strains to infect neurons.

This study determines the structures of EEEV and SFV spike glycoproteins bound to VLDLR, revealing distinct binding modes that explain how different alphaviruses use the same receptor.