Manos Mavrakis

SPIN90 selectively activates ArpC5L-containing Arp2/3 complexes to make linear actin filaments, shaping lamellipodial filament orientation and protrusion efficiency in B16 melanoma cells.

This study quantitatively compares the membrane binding and self-assembly of human septin hexamers and octamers using biophysical methods, revealing distinct structural properties and functional implications.

This study shows that mitochondrial redistribution and activity are crucial for apical constriction in Drosophila gastrulation, regulated by the Dorsal signaling pathway.

The paper introduces 4polar3D, a method for 3D orientation imaging of dense actin networks using ratiometric polarization splitting, demonstrating its ability to resolve nanoscale organization in cellular structures.

This paper develops genetically encoded fluorescent reporters to quantify actin filament organization in living cells and tissues using fluorescence polarization microscopy.

The paper identifies a transmembrane domain in septins from C. elegans and primates, showing it is required for membrane association and tissue integrity.