Antoine G. Jegou

The paper shows tropomodulin and leiomodin nucleate tropomyosin clusters on actin filaments, with tropomodulin acting at the pointed end and leiomodin along the entire filament.

SPIN90 selectively activates ArpC5L-containing Arp2/3 complexes to make linear actin filaments, shaping lamellipodial filament orientation and protrusion efficiency in B16 melanoma cells.

This study investigates how cofilin binds and severs actin filaments containing ADP-Pi-actin, revealing that cofilin clusters form preferentially on ADP-actin subunits and severing is slower at ADP-Pi-actin boundaries.

This study shows myosin-X can bundle actin filaments and regulate barbed-end dynamics, suggesting it can initiate filopodia without passive crosslinkers.

This study reveals that MreB filaments in Bacillus subtilis renew their nucleotide state through intrafilament exchange without subunit turnover, linking filament stability to the surrounding nucleotide pool.

This study shows vimentin promotes actin elongation by stabilizing ATP-actin subunits at the barbed end, and it enhances actin nucleation through a direct interaction with ATP-actin monomers.

This study compares actin filament assembly and disassembly kinetics between two yeast species and mammalian actin, revealing faster aging in yeast actins due to the absence of histidine 73 methylation.

The paper introduces a drag flow method to study protein-protein interactions, showing that low forces detach tropomyosin clusters from actin filaments, with detachment rates depending on isoform and force magnitude.

This study shows that inorganic phosphate (Pi) in the Arp2/3 complex stabilizes actin filament branches, with Pi release rates and force-dependent stability affecting branch stability and regrowth.

This study investigates the mechanism of vimentin filament disassembly, revealing continuous self-repair and subunit exchange dynamics that prevent fragmentation.

This paper develops genetically encoded fluorescent reporters to quantify actin filament organization in living cells and tissues using fluorescence polarization microscopy.

This study shows that HIV-1 budding requires MICAL1-mediated actin disassembly at the plasma membrane, with Rab35 also playing a role in this process.

The paper shows that Arp2/3 complex can re-nucleate actin branches without NPF activation after debranching, suggesting a self-repair mechanism for actin networks.

This study reveals how cortactin stabilizes actin branches by interacting with activated Arp3 at the branch site, displacing other nucleation promoting factors.