Kam W. Leong

This paper develops a tumor-targeting engineered bacterium that improves therapeutic efficacy and safety in cancer treatment.

This paper develops a multivalent NET-neutralizer that reduces inflammation in severe sepsis by targeting DNA-histone chromatin complexes while maintaining antibacterial activity.

This study develops nanomaterials that capture cell-free DNA to reduce inflammation in periodontitis and atherosclerosis by modulating macrophage lipid markers.

This study demonstrates that dissociated hippocampal cells can self-organize into network dynamics similar to in vivo cognitive cell assemblies, showing resilience and response to perturbations.

Squidiff predicts transcriptomic changes across cell types in response to environmental stimuli using a diffusion model, enabling in silico screening for drug discovery and precision medicine.

This study shows that targeting protease-activated receptor 2 (PAR2) signaling in organelles using nanomedicines provides sustained analgesia in preclinical models of inflammatory bowel disease.

This study identifies delayed cortical neuron development in 22q11.2DS-associated schizophrenia using brain organoids and single-cell RNA sequencing.

This study investigates GRPR endosomal signaling in pruritus and shows that endosomal targeting of GRPR antagonists is more effective in blocking itch sensation.

This paper introduces a cost-effective, scalable light sheet microscopy framework for high-resolution imaging of living and cleared samples, demonstrating its application on various biological samples.

This study examines the effects of chronic and acute fentanyl exposure on midbrain organoids, finding that chronic treatment arrests neuronal development and alters synaptic pathways.

This paper creates a vascular organoid model with an AKT1 mutation to study Proteus syndrome and finds AKT inhibitors reverse vascular malformations.

Starfysh integrates spatial transcriptomics and histology to analyze tumor microenvironments, identifying disease-specific spatial hubs and immune interactions in breast cancers.

This paper introduces spatial-ATAC-seq, a method for spatially resolved chromatin accessibility profiling at the cellular level, and demonstrates its application in mouse embryos and human tonsil tissue.

The paper identifies Gli1+ stem cells in the enthesis, shows their multipotency and therapeutic potential for tendon regeneration.

This paper develops a programmable probiotic encapsulation system using synthetic biology to enhance therapeutic delivery in mice by controlling bacterial immunogenicity and survivability.