Praveena Prasad

This study shows that β-catenin activation in liver cancer cells reduces mitochondrial pyruvate carrier expression and shifts metabolism from carbohydrate to fatty acid oxidation.

This study examines metabolomic, lipidomic, and enterohormone changes during progression from MASLD to MASH in mice, identifying cholic acid elevation and altered enteroendocrine hormone levels.

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

This study shows Derlin-mediated ERAD of ORMDL3 prevents mitochondrial dysfunction by maintaining sphingolipid homeostasis and ER-mitochondria contact sites.

This study shows that inhibiting purine biosynthesis with mizoribine prevents weight gain and improves metabolic health in mice on a high-fat diet by increasing thermogenesis and reducing food intake.

This study shows that inhibiting IDO1 restores hippocampal glucose metabolism and rescues cognition in Alzheimer's disease models.

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

This study shows that NMN supplementation in aged mice increases kidney inflammation and uremic toxins, suggesting age-specific risks of NAD+ boosting supplements.

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.