Pulin Li

The paper investigates how lipid modifications affect Hedgehog morphogen signaling and gradient formation, revealing a tradeoff between local enrichment and long-range diffusion.

The paper develops a framework combining perturbation screens and transfer learning to reconstruct signaling histories in cells and optimize differentiation protocols.

This study shows that hormone oscillations maintain cellular responsiveness and coordination across cell types by allowing receptor resensitization and buffering kinetic variation.

This study identifies Fgf10 as a Pitx2-sensitive signal that drives asymmetric lung growth by modulating epithelial proliferation during early lung development.

The paper uses single-molecule imaging and spatial transcriptomics to show a spatially graded threat-sensing strategy in lung tissue during influenza infection, with higher PRR expression in inner stroma leading to more potent immune responses.

The paper identifies a mesenchymal progenitor population in the developing mouse lung that generates endothelial cells through integrative vasculogenesis, distinct from classical vasculogenesis and angiogenesis.

The paper reconstitutes planar polarity initiation in an engineered epithelial system, showing collective migration breaks symmetry and drives polarity across scales.

The paper shows SCUBE1 expands Hedgehog gradients by enabling transient diffusion through cell gaps, revealing a topology-limited diffusion mechanism for morphogen signaling.

The paper shows that Scube2 and Shh form a feedback loop that enables the Shh morphogen gradient to scale with tissue size in the ventral neural tube.

This study shows Lhx2 modulates Sonic Hedgehog signaling in retinal progenitors through direct and indirect regulation of pathway components, establishing competence for signaling during early neurogenesis.

The paper identifies GPR132 as a specific receptor for certain oxylipins that enhance hematopoiesis in vertebrates, using bioinformatics and functional assays.