Michael Stumpe

This study identifies VRK-1 as a regulator of chromatin-nuclear lamina interactions in C. elegans, showing its role in stress-induced chromatin reorganization and survival.

The paper describes a protocol for preparing tissue samples for proteome and phosphoproteome analysis using mass spectrometry, including steps for tissue disruption, lipid depletion, and phosphopeptide enrichment.

The paper identifies LSL-1's interaction with chromatin factors to maintain germline transcriptional programs and cell fate in C. elegans.

This study shows autophagy contributes to MHC class II presentation of RA-related peptides in HLA-DRB1*04:01 alleles, with 30% of peptides differing between autophagy sufficient and deficient cells.

This study shows LUBAC activates AMPK and OTULIN restricts it, affecting metabolic responses to energy stress in cells, mice, and flies.

The paper investigates how Medicago truncatula sanctions Sinorhizobium meliloti cheaters in nitrogen-fixing symbiosis by altering resource exchange and analyzing metabolic and proteomic changes in nodules.

The paper identifies O-mannosylation and protein maturation as therapeutic targets in BRAF fusion oncogenesis by showing their necessity for fusion-induced transformation.

The paper identifies two mitophagy peaks during retinal development, one PINK1-independent and one PINK1-dependent, linked to oxidative stress and RGC differentiation.

The paper investigates dermokine's role in keratinocyte adhesion through multi-omics analysis, showing that dermokine loss increases p120 phosphorylation and reduces cell-cell adhesion.

This study identifies the RXLR-EER motif as critical for directing oomycete effectors to the haustorial neck for host cell entry.

This study uses targeted proteomics to analyze protein degradation patterns during autophagy, revealing differential responses of selective autophagy receptors to various stimuli.

This study identifies BAG2 as an effector of the ULK1 complex that modulates AMBRA1 localization to regulate autophagy initiation under different nutritional conditions.

This study identifies androglobin (Adgb) as essential for male fertility in mice, showing its role in spermatogenesis and flagellum formation through interactions with Sept10.

This study shows that deleting Per2 in glial cells of mice alters mood-related behaviors, reducing despair and anxiety with changes in neurotransmitter levels.