Hisashi Sawada

This study shows that PAI-1 deficiency leads to early cardiac hemorrhage and fibrosis under hemodynamic stress, with mutations in the protease-inhibitory domain causing similar pathology.

This study identifies that adventitial progenitor cells differentiate into elastogenic SMC-like cells, contributing to false lumen remodeling through de novo elastic fiber formation following aortic dissection.

This study shows that AngII infusion worsens aortic pathology in Fbn1C1041G/+ mice, leading to aortic rupture and branch aneurysms.

This study investigates whether metformin reduces AngII-induced aortic aneurysms in LDLR-/- mice and finds it does not.

This study shows that cilostazol and sildenafil do not prevent BAPN-induced thoracic aortopathy in mice.

The paper examines transcriptomic changes in smooth muscle cells and fibroblasts from different embryonic origins in the proximal thoracic aorta under AngII infusion, finding modest differences between origins.

This study shows that deleting megalin in renal proximal tubule cells does not reduce atherosclerosis but causes tubulointerstitial nephritis in male mice fed a Western diet.

This study shows that BAPN induces distinct aortic pathologies in the ascending and descending thoracic aortas of young mice, with different structural and cellular changes in each region.

This study investigates the functional role of conserved sequences in the loop and β-sheet regions of angiotensinogen, showing that mutations in either region individually have no effect, but combined mutations impair AGT secretion.

This study shows that renal angiotensinogen in nonhuman primates is mainly derived from the liver, as evidenced by reduced renal AGT levels after liver-specific AGT inhibition.

This study identifies robust gene-phenotype associations by analyzing rare loss-of-function variants in exome-wide data linked to electronic health records.