Sohei Ito

This study shows that PAI-1 deficiency leads to early cardiac hemorrhage and fibrosis under hemodynamic stress, with mutations in the protease-inhibitory domain causing similar pathology.

This study identifies that adventitial progenitor cells differentiate into elastogenic SMC-like cells, contributing to false lumen remodeling through de novo elastic fiber formation following aortic dissection.

This study investigates whether metformin reduces AngII-induced aortic aneurysms in LDLR-/- mice and finds it does not.

This study shows that cilostazol and sildenafil do not prevent BAPN-induced thoracic aortopathy in mice.

The paper examines transcriptomic changes in smooth muscle cells and fibroblasts from different embryonic origins in the proximal thoracic aorta under AngII infusion, finding modest differences between origins.

This study shows that BAPN induces distinct aortic pathologies in the ascending and descending thoracic aortas of young mice, with different structural and cellular changes in each region.

This study investigates the functional role of conserved sequences in the loop and β-sheet regions of angiotensinogen, showing that mutations in either region individually have no effect, but combined mutations impair AGT secretion.