Feng He

This study investigates the roles of PIP5KI isoforms in retinal function and health using mouse models, revealing differential and compensatory effects on photoreceptor degeneration and function.

The paper analyzes 3,313 genetically engineered mouse lines to identify gene essentiality as the main factor affecting Cas9-based genome editing success.

The paper uses cryo-electron tomography to reveal structural features of photoreceptor cilia in mouse retinas, including the basal body, Y-links, and ciliary necklace.

This study creates a mouse model of retinitis pigmentosa with a P23H-Rho-RFP fusion to study subcellular localization and disease progression, finding slow retinal degeneration and ER accumulation of mutant protein.