Guillaume Lebon

This paper develops a photoswitchable positive allosteric modulator of mGlu5 that activates the receptor in response to light, demonstrating reversible isomerization and light-dependent activity.

This study reports cryoEM structures of mGlu5 receptor with different PAMs, showing how PAM binding modulates receptor conformation and function.

This study shows that PIEZO1 is essential for outflow tract and aortic valve development in zebrafish and identifies PIEZO1 variants linked to bicuspid aortic valve in humans.