Daniel A. Lawrence

This study shows that PAI-1 deficiency leads to early cardiac hemorrhage and fibrosis under hemodynamic stress, with mutations in the protease-inhibitory domain causing similar pathology.

This study identifies occludin's role as a dynein adaptor regulating vascular permeability and collateral angiogenesis through phosphorylation-dependent trafficking.

The paper identifies SorlA as a novel PAI-1 interactor required for lung fibrosis, showing SorlA deficiency protects against fibrosis in mice and SorlA is upregulated in human IPF lung tissue.

This paper develops micrometer-scale tPA beads that enhance plasmin generation and fibrinolysis, achieving rapid thrombus removal in a mouse stroke model with lower doses than standard tPA.

This study shows that thrombolysis worsens cerebrovascular injury after ischemic stroke by increasing adipose lipolysis, which can be mitigated by VEGF-B antagonism.

This paper demonstrates that tPA-functionalized microwheels, guided by magnetic fields, can efficiently dissolve occlusive thrombi in zebrafish larvae, outperforming systemic tPA delivery.

This study shows imatinib reduces myofibroblast transdifferentiation and fibrotic scarring in ischemic stroke, improving functional outcomes in mice and overlapping with human stroke transcriptome data.