Michael Schotsaert

This study evaluates adjuvants for a SFTSV vaccine, finding that Addavax and SDI enhance neutralizing antibodies and immune memory, with NP as a key target.

This study evaluates an adjuvanted mucosal vaccine in guinea pigs, showing enhanced protection and reduced viral transmission against influenza.

This study identifies the role of mature dendritic cells type 1 in forming, maintaining, and functioning tertiary lymphoid structures in cancer.

This study identifies Tetherin as an immunometabolic checkpoint in adipocytes that restricts type I interferon signaling while preserving glycolytic capacity, improving metabolic homeostasis.

This study shows that TIV vaccination reduces lethality in influenza-infected mice with secondary pneumococcal infections by modulating immune responses and pathogen titers.

This study identifies CLEC4E as a key driver of pro-inflammatory mDC responses in influenza using single-cell network analysis and validates its therapeutic potential in a murine model.

This study compares immune responses to different COVID-19 vaccines in humans, finding distinct interferon programs in myeloid cells based on vaccine type and dose timing.

This study shows that combining TLR7/8 and RIG-I agonists prevents allergic sensitization and reduces influenza severity in OVA-sensitized mice.

This study shows that vaccinated mice experiencing breakthrough influenza infection have transient lung eosinophilia linked to balanced Type 1/2 immune responses without severe pathology.

The paper identifies master regulator modules in human airway epithelial cells reprogrammed by SARS-CoV-2 and finds 11 drugs that reverse these signatures.

This study shows that combining intramuscular mRNA priming with intranasal protein boosting using a combination adjuvant enhances mucosal B- and T-cell responses against SARS-CoV-2 compared to other vaccination regimens.

This study evaluates how lipid nanoparticle (LNP) composition and adjuvant combinations affect immune responses and protection in mice vaccinated against influenza.

This study shows that helpless CD8+ memory T cells, which form without CD4+ help, have transient functional impairments due to prolonged antigen exposure, which resolve over time.

This paper presents a protocol for creating human lung organoid-derived air-liquid interface cultures to study SARS-CoV-2 infection and includes quality control and monitoring methods.

This study shows SARS-CoV-2 infects macrophages in coronary atherosclerotic lesions, causing inflammation that may increase cardiovascular risk.

This study develops a 3D printed lung model to investigate how ventilation affects viral infection and lung responses in vitro.