G. P. van Wezel

The paper identifies RokL6 as a regulator that controls the expression of the MFS transporter SCO1448, which protects Streptomyces coelicolor from glucosamine toxicity by exporting toxic metabolites.

This paper discovers novel actinomycin derivatives, L1 and L2, produced by Streptomyces sp. MBT27 through metabolic analysis and molecular networking, showing their unique biosynthesis involving two metabolic pathways.

This study shows that Streptomyces produce antibiotics more when competing with closely related strains or those sharing biosynthetic pathways, but not when threatened by toxins, and often reduce production under resource limitation.

This study shows that SflA and SflB mutants of Streptomyces coelicolor exhibit hyphal branching and ectopic DivIVA/FtsZ localization during sporulation.

This study uses cryo-electron tomography to show that teichoic acids anchor distinct cell wall lamellae in the apically growing bacterium Streptomyces coelicolor.

The paper introduces decRiPPter, a machine learning and pan-genomic approach to discover novel RiPP classes, identifying 42 new candidate families from Streptomyces genomes.

The paper shows that ferroverdins and bagremycins, two metabolites with different bioactivities, are produced from the same BGC, with their formation depending on iron availability.

This study identifies novel glycerolated quinazolinones produced by Streptomyces sp. MBT27 under glycerol-induced conditions and elucidates their biosynthetic pathway.

This study shows that spatial structure enhances the fitness benefits of streptomycin production in S. griseus by reducing invasion thresholds and enabling competition against susceptible strains.

The paper shows streptomycetes produce ammonia from glycine to kill bacteria over long distances, enhancing their antibiotics' effectiveness.

This study investigates structural and proteomic changes in Vibrio cholerae during the viable but non-culturable state using electron cryo-tomography and proteomic analysis.

This study shows that prodiginine production in Streptomyces coelicolor correlates with programmed cell death, suggesting self-toxic metabolites drive PCD during morphogenesis.

SParticle analyzes filamentous microorganism morphology in submerged cultures using automated image analysis and is available as an ImageJ plugin.