Elizabeth A. Campbell

This study identifies MtvS1 and MtvS2 as regulators of the Francisella type V-A CRISPR-Cas system and shows they interact with RNA polymerase to modulate gene expression.

This study shows desiccation-induced DNA damage in Mtb leads to mutations and drug resistance by affecting DNA repair and gene expression.

The paper uses AI-based protein-protein interaction predictions to characterize protein function in mycobacterial pathogens, identifying key interactions and functions for previously uncharacterized proteins.

This study resolves the structural basis of Mfd loading onto stalled elongation complexes by visualizing intermediates at 3.5 Å resolution using cryo-electron microscopy.

This study shows that RNA polymerase inhibitors prevent RH-FL closure, destabilizing the trigger loop and inhibiting the nucleotide-addition cycle.

The paper shows that KorB, a DNA-sliding clamp, switches to a repressor role with KorA to mediate long-range gene silencing on plasmid RK2.

The paper shows RapA disrupts post-termination complexes in E. coli to prevent R-loop formation and maintain genome stability.

This study determines cryo-EM structures of SARS-CoV-2 NiRAN domain catalytic intermediates, revealing structural mechanisms for NMPylation and deRNAylation/capping, and explaining substrate preference for capping.

This study identifies MtbNusG as a pro-pausing transcription factor that stabilizes paused RNAP through specific structural interactions, with implications for NusG function across domains of life.

The paper constructs an atomistic model of the SARS-CoV-2 replication-transcription complex, revealing its hexameric structure centered on nsp15 and detailing interactions between viral proteins.

The paper deciphers the DNA-specificity code of ECF σ factors to predict their regulons and reveals their varied regulatory roles in bacterial gene regulation.