William B. Klimstra

This study identifies three HS-binding sites on EEEV E2 glycoprotein that contribute to both HS and protein receptor-dependent infection, affecting disease and mosquito infectivity.

This paper develops a rule-based kinetic model of EEEV replication in mammalian cells, calibrated with experimental data, revealing ribosome density on viral RNA as critical for rapid replication and identifying transcription as a therapeutic target.

This study tests if polyclonal SARS-CoV-2 antibodies enhance disease in ferrets, finding no significant differences in symptoms or viral shedding between antibody-treated and control groups.

This study shows that phagocyte-expressed glycosaminoglycans mediate species-specific vascular clearance of alphaviruses, with some viruses being cleared faster than others.

This study shows that intranasal IFNα treatment suppresses VEEV replication and neuroinvasion in olfactory sensory neurons, improving survival and delaying encephalitis onset in mice.

This study identifies multiple VLDLR binding sites used by EEEV and develops a decoy receptor to neutralize infection.