Christine Guo Lian

RECON selects regions of interest from H&E images and reconstructs molecular profiles across entire slides at single-cell resolution for both transcriptomics and proteomics.

This study shows that immunogenic tumor mass dormancy, not cell-level quiescence, persists in residual melanoma lesions after immunotherapy, with active tumor cells and immune interactions.

This study shows that the concave topography of rete ridges influences epidermal stem cell differentiation and function, with changes in topography contributing to skin aging.

The paper identifies melanoma differentiation and immune exhaustion as predictors of tumor progression and therapy response in in-transit melanoma patients through multiomic profiling.

This paper introduces 3D CyCIF, a method for high-plex 3D profiling of cell states and immune niches in human tumors, revealing detailed spatial interactions and cytokine niches previously unattainable in thin sections.

The paper maps spatial patterns of tumor cell dedifferentiation and plasticity in melanoma by analyzing RNA and protein expression across 300 histological domains.

The paper identifies a BMP-dependent attractor state in melanoma precursor cells that precedes neural crest fate and is associated with ID1 expression in human melanoma.

This study shows PRAME expression in melanoma is negatively regulated by TET2-mediated DNA hydroxymethylation, with reduced 5hmC levels correlating with PRAME upregulation.

SpatialCells automates the analysis of spatially resolved multiplexed single-cell data to characterize tumor microenvironments, enabling efficient feature extraction and downstream machine learning applications.

This study shows testosterone increases fibrosis and scar strength in a swine model, suggesting androgenic steroids contribute to pathologic scarring through extracellular matrix changes.