Christopher M. Wintersinger

This study demonstrates that DNA origami vaccine nanoparticles enhance both humoral and cellular immune responses against infectious diseases like SARS-CoV-2, HIV, and Ebola.

This paper demonstrates that reusing excess staple oligonucleotides with replenishment can reduce DNA origami production costs by up to 80%.

This study developed a DNA origami-based cancer vaccine that co-delivers antigen and CpG immune adjuvant with an optimal nanospacing for Th1 immune polarization.

Crisscross polymerization of DNA-origami slats enables the creation of micron-scale structures with uniquely addressable nanoscale features.

This paper introduces a method for robust nucleation control in DNA-based self-assembly using crisscross polymerization, achieving strictly seed-initiated growth without spontaneous nucleation.