Yilin Chen

This study develops a microfluidic device to enrich pancreatic cancer-derived extracellular vesicles based on charge, linking KRAS status to EV secretion and surface charge.

This study constructs a large-scale cancer-specific TF-DNA interaction network and identifies potential therapeutic targets among oncogenes and TFs.

This study shows that Cbfβ deficiency leads to OA by altering Wnt/β-catenin, Hippo/Yap, and TGFβ signaling, and that local Cbfβ overexpression protects against OA in mice.

The paper uses cryo-TEM and a segmentation model to analyze EV architecture, finding consistent structural heterogeneity across different sources and purification methods.

The paper introduces paired yeast one-hybrid assays to detect DNA-binding cooperativity and antagonism between transcription factors and demonstrates their application across various TF pairs.

The paper analyzes H3 nucleosome occupancy changes in aging mouse tissues and neural stem cells, finding local chromatin accessibility shifts linked to pro-inflammatory gene expression.