Brittany R. Davidson

This study shows that ARID1A loss in ovarian clear cell carcinoma maintains increased mitochondrial respiration and bioenergetic efficiency under metabolic challenges, with specific ETC protein changes.

The paper uses local gene editing in mouse tumor models to discover a novel fibroblast state and its impact on the tumor microenvironment.

The paper identifies coordinated variation between immune systems and microbiomes in healthy humans, linking it to tonic interferon states.

The paper shows congenital CMV infection leads to oligoclonal expansion of cytotoxic γδ T cells with fetal-like TCR features in neonates.

The paper introduces anticlustering to balance batches and minimize batch effects in high-throughput sequencing, showing improved balance compared to existing methods.

The paper identifies a potent effector state among exhausted CD8 T cells in tumors using multimodal CITE-Seq, showing enhanced cytokine production and tumor-killing ability.

This study shows that a short-term high-fat diet during the onset of psoriasis worsens disease severity through immune system changes, even after returning to a normal diet.

The paper identifies two immunological subtypes of Sjögren's disease using single-cell RNA sequencing, highlighting distinct IFN-I signatures and transitional B cell characteristics.

This study creates a comprehensive single-cell atlas of the maternal-fetal interface, identifying cell-type-specific dysregulation in pregnancy complications.

The paper introduces new tools for the auxin-inducible degron system in C. elegans, enabling conditional protein depletion through CRISPR/Cas9-mediated genome editing.