NeurosciencebioRxivPreprint
Vorinostat Rescues SQSTM1 Palmitoylation and Restores Dysfunctional Autophagy in Huntington Disease
Yasmeen Alshehabi, Fatima Abrar, Milena Rabu…·Dale D. O. Martin
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University of WaterlooORCID 0009-0004-0366-6665Unclaimed ORCID profile · follow to get notified of new preprints
2 papers
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Yasmeen Alshehabi, Fatima Abrar, Milena Rabu…·Dale D. O. Martin
Fatima Abrar, Martyn C. Davies, A. Kumar…·Dale D. O. Martin
The paper shows reduced S-acylation of SQSTM1/p62 in Huntington disease impairs autophagy by blocking autophagic flux and causing empty autophagosomes.