Takeru Fujii

The paper shows SOX2 terminates trophectoderm competence in inner cell mass by closing Hippo signaling-responsive enhancers through chromatin closure.

This study identifies Il1r2 as a marker for slow-cycling epidermal basal cells and develops a genetic tool for lineage tracing and IL-1 signaling modulation.

The paper shows that chromatin modifications around genes fluctuate with transcriptional activity in mouse embryonic stem cells, revealing minute-scale coupling between histone marks and transcriptional bursts.

The paper introduces PECAbs for high-specificity multiplexed imaging of cell states and combines them with seq-smFISH to classify cells and identify signal activation states in human tissue.

The paper examines enhancer-promoter interactions in mouse embryonic stem cells, finding that transcriptional activity increases genomic viscosity, stabilizing these interactions.

The paper introduces DFC, a method using adaptive LASSO logistic regression to identify a small subset of genes that distinguish cell populations, addressing issues with P-value inflation in single-cell transcriptomics.