A method for inducing a senescence trend in mesenchymal stem cells using D-galactose
Xiaoming JiiD, Xiaoyu Zhou, Tingting Chen, Chunchun Duan, Wenjing TianiD, Liyang Zhu, Yan MaiD, Liyang GaoiD
Abstract
The aging of the body is accompanied by a decline in tissue function, and this decline mainly stems from the aging of tissue stem cells. Therefore, they play a crucial role in the aging of the body.This study explores the biological characteristics of senescent hUCMSCs by establishing a replicative senescence model of hUCMSCs and a rapid senescence model induced by D - galactose (D-Gal), and analyzing the proliferative capacity, cell viability, cell cycle, pluripotency, and reactive oxygen species (ROS) levels of senescent hUCMSCs.
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