J. Gil

Identifying Ferroptosis Inducers, HDAC, and RTK Inhibitor Sensitivity in Melanoma Subtypes through Unbiased Drug Target Prediction

This paper identifies potential drug targets and predicts treatment efficacy and resistance in melanoma subtypes using proteogenomic data and drug sensitivity analysis.

Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome

This study shows that S6K1 deletion reduces inflammation and immune infiltration in aged livers, suggesting it suppresses the inflammatory SASP, contributing to healthspan benefits.

Histopathology-assisted proteogenomics provides foundations for stratification of melanoma metastases

This study integrates histopathology and proteogenomic data from melanoma metastases to identify subtypes and risk factors, offering a basis for personalized treatment strategies.

Proteogenomic Characterization Reveals Therapeutic Opportunities Related to Mitochondrial Function in Melanoma

This study uses proteomics to analyze mitochondrial function in melanoma samples, finding dysregulation linked to patient survival and treatment responses, and proposes therapeutic strategies targeting mitochondrial pathways.

SARS-CoV-2 variants show temperature-dependent enhanced polymerase activity in the upper respiratory tract and high transmissibility

This study shows SARS-CoV-2 variants with P323L or P323L/G671S mutations in NSP12 have enhanced polymerase activity at 33°C and higher transmissibility in ferrets.

Proteogenomics Reveals how Metastatic Melanoma Modulates the Immune System to Allow Immune Evasion

This paper analyzes proteogenomic data from melanoma patients to show how metastatic melanoma alters metabolism and immune responses to evade immune detection.

The SINGLE FLOWER (SFL) gene encodes a MYB transcription factor that regulates the number of flowers produced by the inflorescence of chickpea.

This study identifies the SFL gene in chickpea as a MYB transcription factor that regulates the number of flowers per secondary inflorescence by controlling the activity duration of the I2 meristem.

Cardiac glycosides cause selective cytotoxicity in human macrophages and ameliorate white adipose tissue homeostasis

This study shows cardiac glycosides induce cytotoxicity in human macrophages and improve white adipose tissue homeostasis in obese patients.

Galactose-modified duocarmycin prodrugs as senolytics

This study develops galactose-modified duocarmycin prodrugs that selectively kill senescent cells by targeting lysosomal β-galactosidase, showing therapeutic potential for age-related diseases.

Effects of Topical Antimicrobial Formulations on Pseudomonas aeruginosa Biofilm in an In vivo Porcine Burn Wound Model

This study evaluates the effectiveness of different silver-based wound dressings in reducing Pseudomonas aeruginosa biofilms in a porcine burn wound model, finding that silver oxynitrate powder most effectively reduced bacterial counts.

Effector prediction and characterization in the oomycete pathogen Bremia lactucae reveal host-recognized WY domain proteins that lack the canonical RXLR motif

The paper identifies and characterizes WY domain-containing effector proteins in Bremia lactucae, revealing evolutionary divergence from Phytophthora spp. in RXLR motif usage and host recognition.