Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets.
Claire Vinel, James R. BootiD, Weiwei Jin, Nicola PomellaiD, Alexandra Hadaway, Charles A. MeiniD, Nicolae Radu ZabetiD, Silvia MarinoiD
Abstract
Analysis of chromatin remodelling in neoplastic stem cells as compared to ontogenetically related neural stem cells, reveals multifactorial epigenetic regulation of signalling pathways known to contribute to glioblastoma development. It also identifies novel epigenetically regulated druggable target genes on a patient-specific level, including SMOX and GABBR2 which could be further developed for future translational approaches to more effectively treat this neoplasm.
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