experimental assay

This study identifies coding region changes in YAP1 that contribute to body size differences among rodents by showing increased growth-promoting activity in capybara YAP1 compared to mouse and vole YAP1.

This study examines how self-questions drive scientific reasoning in problem solving by analyzing think-aloud interviews of undergraduate life science students.

GraphExperiment provides an R/Bioconductor package to store and manipulate high-dimensional quantitative data alongside associated networks in a unified framework.

This study develops a scalable method to generate functional adipoids from hiPSCs, which mimic human adipose tissue and can be used for metabolic disease research and drug screening.

This study investigates how different molecular crowders affect the magnetic field-dependent fluorescence and recovery kinetics of MagLOV2 in E. coli lysate.

The paper identifies cyclic peptides that selectively bind to a cotranslational folding intermediate of β-galactosidase, revealing a druggable pocket formed during translation.

The paper identifies Saccharomyces cerevisiae and Saccharomyces jurei hybrids with improved oenological traits for wine fermentation.

SpaceBlocks is a workflow for reproducible, expert-supervised spatial transcriptomics analysis across platforms, identifying new cell types and differentially expressed genes in multiple datasets.

This study identifies the pituitary as a conserved regulator of regeneration across vertebrates, showing its role in limb and fin regeneration through prolactin and growth hormone signaling.

This study shows that lymphangiogenesis is essential for healing and survival after laryngotracheal injury in mice, as blocking it leads to worse outcomes.

This study examines how fentanyl and fentanyl-xylazine co-exposure affect mitochondrial transcription in human trophoblasts, showing suppression in syncytiotrophoblasts and discordant regulation with FMX.

This study examines LAMA2 deficiency in mice, showing altered Schwann cell calcium homeostasis and increased nerve inflammation into adulthood.

This study identifies a novel N-terminal region in TET1 that binds nucleosomes, enabling chromatin association in mouse embryonic stem cells through structural and biochemical validation.

The paper uses a multi-modal platform to profile single-cell stress responses in human cell lines, finding a shared stress response program with cell-specific magnitude variations.

The paper presents the first chromosome-scale reference genome for Mytilus planulatus, revealing structural variation and population structure in mussels.

This paper introduces an adjuvant (iCTA) that enhances in vivo CAR-T therapy against solid tumors by improving T-cell recruitment, antigen presentation, and tumor microenvironment.

This study shows CD19-CAR T-cell therapy depletes EBV+ autoreactive B cells and resets their repertoire, leading to sustained remission, while rituximab does not.

The paper develops a new transposon-induced model to identify cancer drivers in mice and shows similarities in driver landscapes between mice and humans.

This study shows GDF15 enhances NAD+ salvage and reduces immune response in mitochondrial disease by upregulating NMRK2 and modulating redox homeostasis.

This paper develops 3D printed EPR sample tubes with complex cross-sections to enhance signal sensitivity in aqueous samples, validated through simulations and experiments.

This study identifies a two-residue C-terminal truncation variant in AID causing adult-onset HIGM2 and shows it disrupts CSR and SHM.

This study evaluates the immunotoxic effects and metabolism of enniatins and beauvericin in human intestinal models, finding limited acute toxicity but distinct inflammatory responses and transport differences.

This study shows that elevated α-synuclein increases basal mitophagy in Parkinson's dopamine neurons, leading to mitochondrial dysfunction and neuronal activity deficits, which can be reversed by DRP1 inhibition.

The paper identifies nanobodies against PvAMA1 that inhibit Plasmodium vivax and falciparum invasion by binding novel epitopes distinct from known antibodies.

The paper uses expansion microscopy to reveal the repeat-subunit organization and multi-domain architecture of human mitotic centromeres, including specialized histone modifications.

The paper investigates how vision and touch coordinate during texture exploration, finding that touch can lead vision when texture information is critical, but vision takes the lead when visual cues are more informative.

The paper shows that somatic variants' transcriptomic impact depends on cellular context, not just sequence, using single-cell transcriptomics and new tools.

This study examines how different concentrations and durations of cigarette smoke condensate exposure affect oxidative stress, autophagy, EMT, and cell death in human and mouse RPE cells.