mixed model

Structural conservation of the gabapentinoid binding site in human and Caenorhabditis elegans α2δ subunits: a docking and molecular dynamics perspective

The paper compares the gabapentinoid binding site in human and C. elegans α2δ subunits using docking and molecular dynamics to identify structural and interaction differences.

Suspected distortion of citations in high-impact cancer journals

Molecular oncology papers that textually resemble retracted paper mill papers receive 50 to 100% more citations yet fewer readers, cite one another, and measurably inflate some journals' citation rates.

Delta rhythm and voice familiarity organize neural entrainment in the infant brain

In 30 six-month-olds, 2 Hz syllable sequences selectively raised delta EEG power in right frontal and left temporal clusters; right frontal tuning grew over blocks; voice familiarity altered theta responses.

Fast-ripples are emergent properties of neuronal networks

Most fast-ripples (250-500 Hz) in rat and human recordings are consistent with chance clustering of action potentials; in awake patients, distinct events make up an estimated 37.5% of detections.

Repeated drought induces a reproducible DNA methylation response associated with gene expression in Quercus lobata

Repeated drought in valley oak seedlings induced CHH hypermethylation recurring at the same gene-proximal transposable elements, associated with elevated yet methylation-attenuated expression of nearby genes.

Computational Structure Modeling, Functional Characterization, and Identification of Potential Inhibitors for the cyclic-di-GMP Mediated Biofilm Forming Membrane Protein in Vibrio cholerae

This paper identifies natural inhibitors of a membrane protein involved in biofilm formation in Vibrio cholerae through structural modeling, functional analysis, and virtual screening.

Parallel evolution under constraint shapes echinocandin resistance in Candida auris

Across 681 matched isolates and 22,388 genomes, high-level micafungin resistance in Candida auris arises through recurrent FKS1 hotspot mutations amid strong purifying selection, and FKS2 appears dispensable.

Allosteric pathways govern Gα protein coupling selectivity at promiscuous GPCRs

The paper identifies allosteric pathways that determine G protein coupling selectivity in promiscuous GPCRs using a combination of mutagenesis, simulations, and machine learning.

Evaluating the Impact of Principal Component and Mixed Model Approaches on Polygenic Risk Score Portability to Diverse Ancestries in the UK Biobank

This study evaluates how principal component and mixed model approaches affect polygenic risk score portability across different ancestries in the UK Biobank.

Genetic canalization of nutrient resorption: evidence from a widespread grass under effective salt stress

In 110 common-garden Phragmites australis genotypes, effective salt stress left N, P and K resorption efficiency largely unchanged; efficiency instead tracked phylogeographic lineage, ecotype and latitude.

Brain morphological pattern is associated with the presence, severity, and transition of transdiagnostic psychiatric disorders in preadolescents

In 8,672 ABCD preadolescents, one canonical-correlation-derived brain morphology variate links higher cognition with lower psychopathology and tracks cumulative psychiatric diagnoses and 2-year diagnostic transitions.

Impact of Reduced Chlorophyll Levels in Leaves on Soybean Yield, Seed Composition, Pod/Seed Photosynthesis, and Chlorophyll Levels in Pod and Seed Tissues

Among 25 low-chlorophyll soybean mutants, a Lincoln mutant raised seed protein without yield loss, while Clark-derived Y11/y11 lowered seed oil alongside reduced pod gross photosynthesis.

Behavioral metabolic suppression confounds thermal performance estimates and climate vulnerability assessments in a marine ectotherm

In an undescribed intertidal Urticina anemone, heat-induced closure suppresses measured respiration, and fitted thermal performance curves place the critical thermal maximum far above the 25-30°C lethal range.

Development of an open-pollinated genetic mapping framework to facilitate the identification of QTL in apples

The paper develops an open-pollinated genetic mapping framework for apples to identify QTL, showing that MLMM outperforms MLM and demonstrating the feasibility of OP-based mapping for faster QTL discovery.

From Structure to Dynamics: Activation Mechanism of the G Protein-Coupled Bile Acid Receptor 1-Gs Complex

This study investigates how lithocholic acid modulates GPBAR1 activation and G protein engagement through molecular dynamics simulations and structural analysis.

Physical interactions between pollen and pistil tissues mediate cryptic female choice in Brassica rapa

Brassica rapa pollen tube length after growing through recipient pistil tissue is donor-by-recipient specific, predicts siring success under competition, and matters more in longer-styled recipients.

Visual Cortical Response Variability in Infants at High Familial Likelihood for Autism

Among infant siblings of autistic children, greater trial-to-trial variability in visual P1 latency at 6 and 12 months tracked higher 24-month cognitive and language scores; mean P1 measures did not.

Invasion status stratifies the composition of the human pancreatic cancer perineural niche

Xenium and single-nucleus profiling of 14 human pancreatic tumors shows invaded nerve neighborhoods enriched for classical cancer cells, myCAFs and lipid-handling macrophages but depleted of lymphocytes.

DetectGxT: detecting gene-by-treatment interactions on molecular count phenotypes accounting for allelic additivity

R package DetectGxT fits allelic-additivity nonlinear models with optional donor or polygenic random effects, raising simulated power to detect gene-by-treatment interaction QTLs over linear regression.

A Preparation-Free Mixture-of-Experts Framework for Protein-Ligand Affinity Prediction

This paper introduces HydrAffinity, a mixture-of-experts model for protein-ligand affinity prediction that outperforms interaction-free methods and matches state-of-the-art interaction-based methods.

Neural-vocal phase coupling reveals structured timing in birdsong production

In three singing canaries, sliding-window cross-correlation with surrogate testing shows HVC multi-unit activity and song envelope couple at a few preferred lags (positive, near-zero, negative), correlated or anticorrelated.

Extending Genome-Wide Association Studies to admixed cohorts with high degrees of relatedness

The paper introduces Tractor-Mix, a mixed model method for GWAS in admixed cohorts with high relatedness, improving ancestry-specific association detection and controlling false positives.

Dissociable Neural Responses to Conditioned Social Threats are Modulated by Spatial Proximity in PTSD and MDD

In 50 trauma-exposed veterans, thalamic hypoactivity to near virtual-reality threats tracked both PTSD and MDD severity, while amygdala hyperactivity to far threats tracked only PTSD severity.

Parameterizing the genetic architecture under stabilizing selection

The paper derives an alternative to the beta-model for genetic architecture under stabilizing selection, linking evolutionary theory to mixed models for improved prediction.

PIP2 stabilizes Nav1.5 gating and links receptor signaling to cardiac late sodium current

This study shows PIP2 stabilizes NaV1.5 gating and links Gq signaling to increased late sodium current, with implications for arrhythmias.

Ambient AI Documentation in Clinical Genetics: Perspectives on Implementation and Impact on Burnout

This study evaluates how ambient AI affects burnout in genetic counselors, finding reduced burnout and identifying implementation challenges and ethical concerns.

An age-dependent reversal of the baseline-inflammation to vaccine-antibody-response relationship: a meta-analytic replication in ImmuneSignatures2 with independent influenza cohorts

The paper replicates and quantifies an age-dependent reversal of the baseline-inflammation to vaccine-antibody-response relationship using meta-analytic methods across multiple influenza cohorts.

MoE-Bind: Guiding De Novo Protein Binder Generation with Sparse Experts

MoE-Bind is a sparse Mixture-of-Experts model for protein binder generation that outperforms dense baselines while reducing compute requirements.

Structure-Based Pharmacophore Modeling, High-throughput Screening, and Molecular Dynamics Identify a Novel DrugBank-Derived HIV-1 Protease Inhibitor

The paper identifies BAN as a novel HIV-1 protease inhibitor with binding affinity comparable to 3TL but through a distinct mechanism involving stronger polar interactions and increased protein flexibility.

OmniGene-4: A Unified Bio-Language MoE Model with Router-Level Interpretability

OmniGene-4 is a multi-modal bio-language MoE model that decomposes task performance by router states, achieving strong benchmarks in homology and biological-knowledge tasks while being computationally efficient.