imaging

User-friendly software for high-throughput processing of chlorophyll fluorescence images to assess plant stress responses: fvfmPy and fvfmR packages

The paper introduces fvfmPy and fvfmR, user-friendly tools for automated analysis of chlorophyll fluorescence images to assess plant stress responses, significantly reducing processing time compared to manual methods.

Learning Interpretable Switching Dynamics in Shared Neural-Behavioral Latent Space

This paper introduces SSLD, a framework that learns shared neural-behavioral latent dynamics and private modality-specific variables, showing it accurately reconstructs signals and isolates behaviorally relevant information across multiple datasets.

Archetype analysis of multiplexed antibody imaging reveals interpretable morphological programs in optical pooled screens

The paper introduces CellMAPP and CHART to analyze multiplexed antibody imaging data, revealing modular morphological programs in response to genetic perturbations.

Potassium modulates Phytophthora zoospore motility and flagellar beating through dose-dependent effects

This study shows potassium affects Phytophthora zoospore motility by altering flagellar beating and swimming behavior across different concentrations.

ENDOMETRIAL GLANDULAR EPITHELIAL CELL PLASTICITY DURING POSTPARTUM REGENERATION AND ESTROUS CYCLICITY

This study identifies GE cells as a source for LE regeneration during postpartum and estrous cycles in mice, showing GE cells can dedifferentiate and reprogram to become LE cells.

Insights into Temporal and Spatial Dynamics of Short Association Fiber Formation in the Human Fetal Brain

This study reconstructs the development of short association fibers in the human fetal brain using diffusion MRI and histology validation, revealing their maturation patterns and implications for neurodevelopmental disorders.

Unsupervised 3D classification and characterisation of osteocyte and chondrocyte lacunae in the murine osteochondral unit

This paper presents an automated pipeline to classify osteocyte and chondrocyte lacunae in mouse osteochondral units using microCT, achieving high accuracy without manual intervention or cement line identification.

Mathematical modeling of SUMOylation reveals tissue-specific and dynamic responses to abiotic stress

The paper uses a mathematical model of the plant SUMO cycle to reveal dynamic and tissue-specific SUMOylation responses to abiotic stress.

Microstructural heterogeneity of white-matter aging and its age-dependent coupling to cognition

This study examines age-related changes in white matter microstructure using NODDI and their cognitive associations in adults, finding age-dependent differences in microstructural metrics and their coupling to cognitive domains.

A three-dimensional imaging pipeline for the detection of vasculogenic mimicry in mouse tumor models

This paper introduces a 3D imaging pipeline to detect functionally perfused vasculogenic mimicry in mouse tumor models, providing evidence of its presence and functionality.

Amide I kurtosis maps cardiac amyloid in human tissue by ultrabroadband multiplex coherent anti-Stokes Raman scattering (CARS) microscopy

This paper introduces a label-free method using amide I kurtosis from CARS microscopy to detect cardiac amyloid in human tissue, showing high spatial correlation with Congo red staining.

Macroscopic cerebral energy efficiency corresponds to neuron reorganization in awake and anesthetized mice

This study links changes in cerebral energy efficiency metrics to neural network reorganization in mice under different states.

Rapid simulation of organ-scale oxygen transport for tissue ischemia prediction

The paper introduces a computational toolkit to simulate organ-scale oxygen transport and predict tissue ischemia by analyzing vessel networks and physiological conditions.

VesiScope: A stand-alone tool for the automatic detection, quantification and size analysis of GUVs from phase contrast microscopy images

VesiScope detects and analyzes GUVs from phase contrast images using a YOLOv11 model, enabling accurate and efficient label-free quantification.

Nuclear-BRITE: an enhanced MS2 system for live-cell imaging of nuclear RNAs

Nuclear-BRITE reduces background noise in MS2-based live-cell imaging of nuclear RNAs without affecting their abundance or function.

Large language models unlock the ecology of species interactions

This paper uses large language models to extract species interaction data from citizen science comments, expanding ecological data coverage and enabling new ecological research.

Highlighting the strengths of new wearable fNIRS, precision accuracy microgenetic research designs, and new NeuroDOT processing algorithm to measure change over time in clinical populations for Speech-Language and Hearing Researchers

The paper demonstrates the use of wearable fNIRS and NeuroDOT processing to analyze cortical dynamics over time in a clinical population, showing changes in hemodynamic responses but no improvement in task accuracy.

MICROSTRUCTURAL ORGANIZATION OF CORTICO-SUBCORTICAL FUNCTIONAL CONVERGENCE

The paper characterizes the microstructural organization of functionally converging cortical regions using MRI data from healthy adults, revealing gradients related to cortical hierarchy and target-specific differentiation.

Greater Amyloid Burden in Cognitive Networks in Preclinical Alzheimer's Disease

The paper examines how amyloid-beta accumulation varies across cognitive and non-cognitive brain networks in preclinical Alzheimer's disease and finds higher accumulation in cognitive networks with age and in amyloid-positive individuals.

Machine learning classifies subcellular Golgi morphology from imaging flow cytometry during inflammatory activation: an exploratory study

This study uses deep learning to classify Golgi morphology from imaging flow cytometry data to distinguish LPS-treated from control cells in human and mouse immune cells.

Live-cell imaging and ultrastructure expansion microscopy reveal the dynamic intracellular life cycle of the microsporidian parasite Encephalitozoon intestinalis

Estimating the duration of perceptual moments from early infancy to adulthood

This study estimates the duration of Temporal Integration Windows (TIWs) in visual perception from infancy to adulthood, finding a sevenfold reduction in TIW duration.

Reciprocal control of the stomach and intestine by viscerosensory neurons in caudal brainstem

The paper shows that NPFF neurons in the caudal brainstem control gastric emptying and intestinal transit by responding to duodenal nutrient sensing.

Perceptual decision-making: extending a standardized rodent task to humans

The paper compares perceptual decision-making strategies between humans and mice using a standardized task, finding that instructed humans perform better than uninstructed humans.

Linking live-cell imaging to single-cell sequencing using genetic barcoding

This paper introduces Waldo, a genetic barcoding system that links live-cell imaging phenotypes to single-cell sequencing data for the same cells.

Lung FDG-PET is an early pharmacodynamic biomarker of antiviral efficacy in preclinical influenza

This study shows that lung FDG-PET can detect early antiviral treatment effects in influenza models, correlating with viral load and inflammation.

Widely Used Calculations of Intracranial Volume Provide Inaccurate Estimates in Developmental Cohorts: Evidence and Solutions for the Neuroimaging Community

This study shows that FreeSurfer's eTIV estimates are inaccurate in developmental cohorts and proposes solutions with newer versions.

Designing stimuli for non-invasive, cell-type-specific manipulation of retinal ganglion cell activity

The paper introduces a computational framework to design stimuli that selectively manipulate specific retinal ganglion cell types with minimal impact on others.

Leveraging Chlorination-Based Mechanism for Resolving Subcellular Hypochlorous Acid

This paper introduces HOClSense dyes, a chlorination-based indicator for subcellular HOCl detection, and demonstrates their use in identifying STING pathway-induced HOCl and abnormal HOCl production in Niemann-Pick diseases.

A bacterial endosymbiont with a highly reduced genome forms extensive membrane contact sites with host organelles

The paper identifies extensive membrane contact sites between the mealybug endosymbiont Tremblaya and host mitochondria, suggesting these interactions provide essential membrane and metabolic components.