T-cell and B-cell Immunology

This paper develops a multi-scale mathematical model to integrate BCR/TCR repertoire diversity with immune kinetics, revealing mechanisms of immune imprinting and chronic infection control.

This study identifies cDC1 and cDC2 as essential for TGF-β activation and pTreg induction in the gut, maintaining immune tolerance.

The paper shows that LynA and LynB expression levels determine steady-state phosphorylation of Syk and SHIP1, limiting macrophage signaling without microbial stimulation.

The paper shows that late-entering B cells in germinal centers mainly become memory B cells that recognize less common antigen parts.

This study identifies tissue-specific features of T follicular cytotoxic cells in T. cruzi infection, showing distinct metabolic and functional states in spleen and lymph nodes.

This study shows neonatal human naive CD4+ T cells have higher CD38 expression, linking it to glycolytic metabolism and tolerogenic function compared to adult cells.

This study identifies IκBζ as a key regulator of Treg cell plasticity, showing it drives their conversion into Th2-like effectors and promotes type 2 inflammation.

The paper investigates how antibodies from an ongoing immune response affect interclonal competition in germinal centers, finding that antibody feedback reduces clones recognizing the same epitopes as circulating antibodies.

The study shows that the secondary B cell response magnitude is driven by antibody feedback inhibition, not the number of memory B cells before vaccination.

This study identifies a functional effector CD8+ T cell program in mice and humans that persists into memory after antigen clearance, driven by CD43 1B11 expression.

The paper investigates immediate transcriptional changes in T cells upon direct contact with cancer cells using single-cell transcriptomics and identifies distinct T cell subsets associated with reduced TCR diversity.

The paper identifies distinct plasma cell differentiation routes in humans using single-cell multiomic profiling and functional validation, showing CD30+ intermediates and their regulation by MEF2C and BAFF/APRIL.

The paper identifies memory-specific AP-1 recruitment in T cells, driven by epigenetic changes and co-factor interactions, and links it to disease risk variants.

The paper shows that strong TCR signals from foreign antigens destabilize Tregs, converting them into effector-like cells, while self-antigens preserve stability, revealing a mechanism for balancing immunity and tolerance.

This study shows that TCR signal strength and Eomes determine CD8+ T cell fate in HCC, with high-affinity signals promoting antitumor immunity and Eomes driving exhaustion.

This study examines age-related differences in T follicular helper cell function and their impact on antibody responses across human development.

This study shows CD28 co-stimulation forms signaling condensates with Lck, which PD-1 modulates by binding and disrupting these structures, leading to engineered CAR T cells with improved antitumor activity.

This study identifies transcriptional overmaturation as a key trajectory in naive CD4 T cell aging, showing aging-related changes mirror normal maturation processes.

This study identifies lymph node resident memory T cells (LNRM) as a distinct subset with unique effector capabilities compared to lung resident memory T cells and central memory T cells.

The paper identifies EHF and ELF3 as key ETS transcription factors that sustain AIRE-primed gene expression in post-AIRE mimetic thymic epithelial cells, ensuring central tolerance.

This study shows that Satb1 downregulation prevents autoimmunity by maintaining Tfh cell homeostasis and preventing excessive GC formation and auto-antibody secretion.

This study shows glycosylated GM-CSF expands immunosuppressive B-1b plasma cells and promotes regulatory functions, while non-glycosylated GM-CSF drives pro-inflammatory responses.

The paper compares T cell landscapes in mice with normalized microbial exposure (NME) and specific pathogen-free (SPF) conditions, finding increased effector memory CD8+ T cells in NME mice.

This study shows miR-17~92 promotes T cell proliferation and effector differentiation by regulating metabolic pathways like glycolysis and mTOR activation in viral antigen-specific CD4 and CD8 T cells.

This study identifies Treg-mediated suppression of CD4 T cells and inflammatory myeloid cells as critical for metabolic remodeling of CD8 T cells during the effector-to-memory transition.

This study shows that loss of the transferrin receptor (CD71) in Treg cells leads to tissue-specific inflammation and autoimmunity, highlighting the role of CD71-iron metabolism in Treg stability and function.

This study identifies an early mTOR-dependent window during human T cell activation that programs cytotoxic fate or memory-like state, with transient inhibition promoting memory while preserving effector functions.

This study shows IL-21 enhances cytotoxicity of activated MAIT cells by increasing GrzB and perforin expression without significantly affecting cytokine production.

The paper identifies age-associated Th2-like CD8 memory T cells in human blood and links their accumulation to health conditions like asthma and diabetes.

A CRISPR screen identifies V-type ATPases, PI4K, DDX3X, and MYD88 as key regulators of secretory capacity and lifespan in long-lived plasma cells.