T-cell and B-cell Immunology

The paper infers memory B cell and plasmablast dynamics using statistical methods, finding slow clone degradation and high plasmablast differentiation rates.

This study shows that excess IL-18 protects against CNS autoimmunity by activating CD8 T-cells to suppress CD4 T-cells involved in autoimmune encephalomyelitis.

The paper introduces a scalable TCR synthesis and screening method, TCRAFT, to map antigen reactivity in vitiligo and pancreatic ductal adenocarcinoma.

The paper uses mass spectrometry to analyze proteomic and metabolic changes in CD4⁺ and CD8⁺ T cells during colitis-associated colorectal cancer in mice, revealing distinct adaptations between the two cell types.

This study shows EBF1 regulates the blood-thymus barrier by modulating Claudin-5 expression in thymic endothelial cells, affecting early thymic progenitor influx.

This study compares immune cell composition and activation between hypertensive Bph/2 and normotensive Bpn/3 mice, finding differences in B and T cell subpopulations and reduced cytokine responses in Bph/2 mice.

This study shows that p53 mutations in Li-Fraumeni syndrome mice reduce B cell activation during germinal center reactions without affecting the ratio of activated B cells in dark and light zones.

This study shows that TCF1lo CD8 T cells in tumors can proliferate and persist autonomously, challenging the idea that only TCF1hi cells self-renew.

This study shows that MK2 regulates CD8 T cell inflation during CMV infection by affecting their expansion and differentiation.

The paper develops a 64-plex single-HLA reporter cell panel and analysis tool to identify and characterize allogeneic HLA-specific B cells in sensitized individuals.

The paper introduces cloneXplorer, a platform for generating antigen-specific T cell clones from peripheral blood using conical microwell arrays, and demonstrates its ability to identify and isolate functionally defined T cells.

This paper identifies trehalose monocorynomycolate (TMCM) from C. mast as a stimulator of IL-17-producing γδ T cells at the ocular surface, which protects against corneal infection.

This study shows that early thymic seeding progenitors are crucial for thymic epithelial maturation and regulatory T cell development, preventing age-related autoimmunity.

The paper identifies a PI3Kδ-Foxo1-FasL signaling loop that disrupts Th2 differentiation and epigenetic regulation in CD4+ T cells.

This study shows glucose availability independently regulates CD8+ T cell expansion potential through mTOR-dependent mechanisms, distinct from mitogenic signals.

This study maps the aging trajectories of human γδ T cells using single-cell transcriptomics, revealing non-linear aging with distinct childhood transitions and stability in adulthood.

The paper examines metabolic adaptations in CD4 T cells of critically ill patients with and without sepsis, identifying subset-specific changes linked to immunosuppression and clinical outcomes.

The paper identifies a neonatal liver program that expands regulatory T cells while limiting conventional T cell activation, influencing susceptibility to viral infections and protection against liver disease.

This paper develops a polymer, 1,6 MMA, that suppresses inflammation by reducing IL-2 and increasing mitochondrial ROS in T cells, showing therapeutic potential in collagen-induced arthritis.

This study shows IL-12R signaling sustains T-bet in Treg cells, promoting type 1 specialization and enhancing suppressive function against Th1 responses.

This study uses single-cell transcriptomics and BCR sequencing to analyze B cell development and identifies age-associated subpopulations and key regulatory dynamics.

This paper introduces a capture assay to measure single-cell antibody secretion in B cells during plasma cell differentiation.

This study identifies BTN2A2 as a CD45RO ligand that enhances CD45 phosphatase activity, promoting Treg expansion and reducing Th17 cells, thereby ameliorating autoimmunity in mice and humans.

The paper analyzes TCRβ repertoires from 30,000 individuals to show that TCR diversity is primarily determined by repertoire size and the frequency of the 1,000 most abundant clones, explaining 96% of variance in diversity.

The paper uses in vivo single-cell gain-of-function screening to identify latent transcriptional programs that reprogram T cells into synthetic states with enhanced therapeutic potential.

This study identifies a distinct stem-cell memory subset in CD4+ T cells that is pre-committed to a cytolytic program, showing similarities to CD8-CTLs and demonstrating the potential for generating long-lived cytotoxic CD4+ T cells.

This study identifies a dominant population of IL-10-producing, T-bet-expressing CD4+ Tr1 cells in the small intestine that are shaped by dietary antigens rather than the microbiota.

The paper identifies Treg clonal expansion and immunosuppressive functions in fibrosis induced by synthetic implants, showing their role in modulating stromal cell behavior.

The paper identifies and classifies rare peripheral CD4+CD8+ double-positive T cells using single-cell RNA sequencing and machine learning, revealing their antigen-experienced features and cytotoxic potential.

This study shows that blocking IL-4/IL-13 signaling can reprogram allergen-specific memory B cells from a pathogenic IgE fate to a non-pathogenic IgG2c fate.