Tuberculosis Research and Epidemiology

This study shows that Mafb deficiency in myeloid cells increases susceptibility to Mycobacterium tuberculosis infection in mice by impairing macrophage function and immune cell recruitment.

The paper identifies acylaminooxadiazole derivatives that kill mycobacteria by inhibiting trans-translation and disrupting iron homeostasis.

The paper uses dual RNA-seq in zebrafish to study transcriptional programs in tuberculous granulomas, finding neutrophils and necrosis drive bacterial survival and adaptation.

This study identifies TapA as a regulator of cell separation and intrinsic drug resistance in Mycobacterium tuberculosis by controlling the transition between division and pole growth.

NR4A1 suppresses CD8+ T cell infiltration and cytotoxicity in TB lesions, and its inhibition enhances host resistance to Mtb infection.

This study shows that BCG-infected macrophages release EVs that epigenetically reprogram naive monocytes, enhancing their antimycobacterial activity against Mtb.

This study introduces ASCT to assess bacterial killing in real-time and links drug tolerance to clinical outcomes in mycobacterial infections.

This study investigates how antibiotic tolerance evolves in Mycobacterium tuberculosis during treatment and finds no evidence that it contributes to delayed culture conversion.

This study shows that host membrane microdomains are essential for Mycobacterium marinum to cause membrane damage, escape into the cytosol, and infect cells.

The paper introduces a method using Imaris to track PET-defined lung inflammation sites in Mtb-exposed NHPs, showing correlation with traditional methods and providing additional lesion features.

This study compares delamanid and pretomanid, finding similar bactericidal activity but pretomanid more effectively inhibits M. tuberculosis ribosomal rRNA synthesis.

This paper evaluates alternative study designs for relapsing mouse models of tuberculosis to reduce animal use while maintaining accuracy in estimating treatment efficacy.

This study uses genomic data to show that most multidrug-resistant tuberculosis in Bhutan comes from local transmission, forming a large, recent endemic cluster.

The paper characterizes Mtb strains in Ethiopia using molecular typing, finding high prevalence of Ethiopian and Indo-Oceanic lineages and significant local transmission.

This paper introduces Transcript-Capture Seq to enrich bacterial mRNA from host samples, enabling analysis of the complete Mtb transcriptome in clinical samples and revealing gene expression patterns associated with in vivo bacterial activity.

This study investigates the role of NucS-mediated non-canonical mismatch repair in Mycobacterium tuberculosis and finds it does not significantly affect resistance to key antibiotics.

This study shows that MHC II and CD4 T cell help are essential for pyrazinamide's antitubercular efficacy, revealing a host-mediated mechanism for its in vivo activity.

This paper introduces Tre-DST, a rapid phenotypic drug susceptibility test for Mycobacterium tuberculosis using solvatochromic trehalose probes, showing it can detect drug resistance effectively and quickly.

This study evaluates the CFU-16S rRNA gap in tuberculosis treatment models, finding that the discrepancy is partially due to residual 16S rRNA from dead bacteria and potential transient viable but non-culturable populations.

This study investigates MSMEG_1353's role in lipid metabolism and envelope integrity in M. smegmatis through CRISPRi knockdown, revealing its impact on cell morphology, biofilm formation, and antibiotic susceptibility.

The paper isolates a nanobody specific to Mtb's PstS-1 protein and evaluates its immunoreactivity for potential molecular imaging of tuberculosis granulomas.

The paper shows that nuclear receptor signaling correlates with tuberculosis severity and that LXR activation improves infection outcomes in mice.

This paper evaluates the performance of the gnomonicus tool for predicting antibiotic resistance in Mycobacterium tuberculosis using a diverse testset of 2,663 samples and compares it to TB-Profiler.

This study identifies lipoproteins LpqZ and FecB as essential for mycobacterial cell envelope biogenesis through interactions with enzymes involved in glycoconjugate synthesis.

This study shows neonatal BCG vaccination expands IL-17/IL-22-producing γδ T cells, mediates protection against TB, and induces a microbiome signature linked to gut-lung axis immunity.

This study identifies chlorotonils as potent anti-Mtb agents and shows resistance is mediated by MmpR5-MmpL5.

This study evaluates the immune response and efficacy of co-administering a bovine tuberculosis vaccine (BCG) and a contraceptive vaccine (GonaCon) in badgers, finding no significant adverse effects and potential enhanced BCG protection with booster vaccination.

This paper evaluates a tuberculosis vaccine regimen in mouse models, finding it highly effective in preventing reactivation and acute infection by enhancing specific immune cell populations.

This study identifies compensatory mutations in rpoA/B/C genes of rifampicin-resistant M. tuberculosis isolates in Uganda, finding rpoC/Gly594Glu and rpoC/Val483Ala as the most frequent.

This study shows that inhibiting specific host proteins enhances macrophage killing of intracellular bacteria like Mtb, L. pneumophila, and L. monocytogenes.