Gut microbiota and health

This study uses machine learning to analyze gut microbiota data from Parkinson's disease, RBD, and healthy controls, finding weak to moderate accuracy in distinguishing disease groups but not between PD and RBD.

This study analyzes the pangenome of 34 C. scindens strains and 200 MAGs to understand genetic variability and functional roles in bile acid and steroid metabolism.

This study evaluates the statistical power of differential abundance analyses in microbiome studies and finds they are often underpowered for detecting changes in individual taxa.

This study examines changes in the echidna pseudo-pouch microbiome during lactation, finding a reduction in potentially pathogenic bacteria, and compares wild and zoo-managed animals.

This study shows that anaerobic gut bacteria reduce colonization by ESBL-producing E. coli in mice, with antibiotic treatments altering this resistance.

MetaBiome integrates agent-based modeling and metabolic networks to simulate spatial regulation in gut microbial communities, revealing how microbes adapt to environmental conditions.

This study examines age-related changes in methanogenic archaea in the human gut microbiome, finding that centenarians have a methanogen composition similar to younger adults and that Ca. M. intestini plays a key role in network stability.

This study shows that neonatal microbiota colonization sequentially programs primary and secondary goblet cell functions in the colon, with MyD88 and Duox2 playing key roles in mucus barrier and sentinel cell development.

This study shows that gut microbe-derived TMA affects circadian rhythms through the host receptor TAAR5, impacting metabolism and behavior in mice.

This study analyzes the gut microbiome of humpback whales during feeding and fasting periods, revealing significant taxonomic and functional changes associated with migration and fasting.

This study shows that a dairy co-product enriched in milk fat globule membrane reduces cognitive impairment in aging rats by modulating gut Faecalibaculum rodentium metabolism.

This study uses metagenomics and metabolomics to show age-related gut microbiota and metabolite changes in hamsters with experimental COVID-19, linking them to disease severity and recovery.

This study investigates gut microbiota changes in CDKL5 deficiency disorder mouse models and shows that antibiotic treatment improves neurological outcomes and microglial function.

This study investigates how the gut microbiome interacts with aging and dietary restriction in mice, finding that host genetics significantly influence microbiome features and that dietary restriction does not rejuvenate the microbiome.

DEBIAS-M corrects processing bias in microbiome data, improving cross-study generalization of prediction models by learning interpretable bias-correction factors.

This study uses multi-omics and metabolic modeling in mice to show that aging reduces host-microbiome metabolic interactions, affecting key host pathways involved in intestinal barrier function and homeostasis.

This study shows lactulose consumption selects for E. coli mutations that enhance its metabolic fitness and colonization, increasing infection risk in cirrhosis patients.

This study examines how ginger-cayenne tibicos affects faecal microbiota and SCFA production in prediabetic and healthy adults using an in vitro model.

The paper characterizes gut microbiomes in rural Honduras, identifying novel species and host-microbiome associations through metagenomic sequencing and genomic data integration.

This study investigates the gut microbiome in early age-related macular degeneration (AMD) and finds distinct microbial signatures associated with the condition, which shift with dietary intervention.

This study shows that Mabisi, a traditional fermented food, suppresses pathogen invasion in gut microbiota by modulating microbial composition and increasing short-chain fatty acid production.

This study identifies poor prognosis in IBD-related colon cancer due to gut dysbiosis and immune response failure, linked to microbial imbalance and altered gene expression.

This study shows gut bacteria produce lactate that increases lung epithelial mitochondrial activity and worsens acute lung injury.

This study evaluates how dietary choline and fasting conditions affect blood TMAO levels in rats, finding that high choline diets and non-fasting states increase TMAO, with implications for biomarker reliability.

This study identifies Sutterella sp. as a commensal pathobiont that inhibits IL-22 production and AhR activity, offering insights into gut inflammation regulation.

The paper compares gut microbiomes of Parkinson's disease and inflammatory bowel disease patients, finding shared depletions in butyrate-producing bacteria across multiple datasets.

The paper introduces LIMON, a statistical pipeline for analyzing longitudinal microbial omics data, and demonstrates its ability to identify time-dependent microbial interactions in infant microbiome and diet datasets.

This study identifies early gut microbiota changes in alpha-synuclein transgenic mice, linking microbial dysbiosis to Parkinson's disease progression.

The paper compares oral and gut microbiota in IBD patients to determine which provides better diagnostic potential, finding saliva has higher effect sizes for certain strains.

This paper evaluates using short-read 16S rRNA sequencing of multiple variable regions to achieve species-level resolution and assesses sample collection impacts on results.