Parkinson's Disease Mechanisms and Treatments

This study shows that midbrain dopamine loss in a mouse model of Parkinson's disease reduces thalamocortical input to the motor cortex while increasing its output.

This study examines changes in GDNF receptor expression in the striatum and substantia nigra following a nigrostriatal lesion in rats, finding differential expression patterns of GFR-1 and RET that may impact GDNF therapeutic efficacy.

The paper investigates the regulatory role of the NSL complex in Parkinson's disease by analyzing gene expression and regulatory networks in brain tissues.

This study compares anatomical and diffusion MRI for Parkinson's disease detection using deep convolutional neural networks, finding that dMRI-based models show promise for classification.

The paper investigates the neuroprotective effects of polyphenol-rich extracts against paraquat and rotenone-induced neurotoxicity in Parkinson's disease models, identifying mechanisms involving antioxidant pathways and mitochondrial function.

The paper examines TFEB subcellular localization in Parkinson's and Lewy body disease brains, finding altered distribution linked to disease stages and GBA variants.

This study shows that reducing mutant Lrrk2 in macrophages decreases lysosomal tubule formation and pro-inflammatory responses, suggesting potential therapeutic benefits for LRRK2-related Parkinson's but possible immune system side effects.

The paper examines MAPT haplotype frequencies in Nigerian Africans and finds no association between the H1 haplotype and Parkinson's disease risk or age at onset.

The paper identifies parallel neurodegenerative phenotypes in fibroblasts and iPSC-derived dopamine neurons from sporadic Parkinson's disease patients, revealing shared and distinct molecular and cellular alterations.

This study analyzes resting-state MEG data to show that Parkinson's disease is associated with widespread changes in cortical aperiodic activity, specifically increased λ values across most brain regions.

This study shows that phasic dopamine release in mice is not essential for basic motor behaviors, as motor functions remain intact despite near-complete loss of activity-dependent dopamine release.

This study shows that mice with severe loss of nigral dopamine neurons due to mtDNA mutations still maintain motor function through preserved striatal innervation.

This study shows that overexpression of human alpha-synuclein in rats leads to gut microbiome dysbiosis, altered metabolites, and aging-related changes that can be modulated by antibiotics.

The paper investigates if minor hallucinations in Parkinson's disease are linked to frontal theta oscillations and cognitive decline, finding a correlation between these factors and later cognitive impairment.

The paper visualizes alpha-synuclein inclusions and iron deposition in M83 mouse models of Parkinson's disease using in vivo imaging and ex vivo validation techniques.

This study examines the behavioral effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson's disease model mice, finding both beneficial and adverse effects with chronic treatment.

This study shows that defects in mitochondrial biogenesis, not mitophagy, are the primary cause of mitochondrial alterations in PINK1-deficient human dopamine neurons.

The paper shows that thalamostriatal degeneration impairs goal-directed behavior in rats, but this deficit can be reversed by enhancing striatal cholinergic activity with selegiline.

This study uses diffusion MRI and histopathology to show that microstructural changes in the substantia nigra and its tracts in Parkinson's disease correlate with dopaminergic loss and Lewy neurite pathology.

The paper uses machine learning to identify candidate genes, variants, and pathways potentially linked to Parkinson's disease from GWAS loci and genomic data.

The paper identifies the NSL complex's role in Parkinson's disease by analyzing its mitochondrial interactome and linking it to PD-associated genes and pathways.

This study shows UBL3 interacts with alpha-synuclein in cells and this interaction is reduced by osimertinib treatment.

This study evaluates the mouse neural precursor cell line SN4741 as a proxy for midbrain dopaminergic neurons using genomic techniques and finds it lacks key dopaminergic markers and chromatin features.

This paper shows TPPP forms liquid condensates and aggregates in Multiple System Atrophy, linking its condensate property to microtubule nucleation and disease pathology.

The paper shows that combining α-synuclein fibrils with immune challenges causes Lewy body-like inclusions in human dopaminergic neurons, while cortical neurons do not form such inclusions.

This study shows that phosphorylation of 14-3-3{theta} at S232 reduces its ability to inhibit LRRK2 kinase activity, particularly for G2019S LRRK2, but not for R1441G LRRK2.

This study uses 18F-DOPA PET imaging to identify a dopaminergic deficit in a rat model with a G51D α-synuclein mutation, showing reduced dopamine turnover and striatal asymmetry in aged animals.

This study develops a machine learning pipeline to predict Parkinson's disease severity using CSF-MS data and identifies potential biomarkers.

The paper combines epidemiological pesticide exposure data with iPSC-derived dopaminergic neuron screening to identify and classify pesticides linked to Parkinson's disease.