Epilepsy research and treatment

This study identifies presynaptic targets in the entorhinal-hippocampal circuit that effectively suppress seizures using low-frequency stimulation in a mouse model of MTLE.

This paper introduces a photothrombotic stroke model in mice that reproduces human epilepsy electrographic biomarkers, showing increased spike ripples and delta power in the stroke hemisphere.

This paper proposes an autoregressive modeling approach for identifying and controlling epileptic seizures using real data, showing effectiveness in attenuating seizures and driving signals to interictal stages.

This study identifies subregional cerebellar atrophy patterns in epilepsy syndromes using MRI data from 1,602 patients and 1,022 controls, finding significant volume loss in posterior lobe regions.

This study uses computational models to explore seizure onset and propagation in mice brains and identifies strategies to limit seizure spread.

This study creates a mouse model of mosaic Slc35a2 knockout to study its impact on cortical development and epilepsy-related traits.

The paper analyzes the expression patterns of epilepsy-associated genes across tissues and brain cell types, revealing distinct expression-phenotype correlations among gene classes.

This study identifies a link between hypothalamic orexin neuron activity and seizures in a mouse model and shows that targeting this activity with deep brain stimulation can reduce seizures.

This study shows that impairments in parvalbumin interneurons due to SCN8A mutations cause synaptic transmission deficits and seizures in a mouse model of SCN8A epileptic encephalopathy.

This paper introduces an automated algorithm to detect seizure-related events in calcium imaging data, showing accurate detection of pre-ictal spikes and seizure wave propagation in mice.

This study investigates the effects of ARX poly-alanine mutations in human brain organoids, revealing altered interneuron migration and cortical neuron development.

The paper investigates cortical development in a rat model of Absence Epilepsy and finds that the transient hyperconnectivity from deep to superficial layers is absent, contributing to pathological neural dysfunctions.

This study shows that loss-of-function mutations in zebrafish slc13a5 cause epilepsy-like phenotypes, which are rescued by blocking NMDA receptor signaling.

This study evaluates the therapeutic potential of Org 34167, an HCN channel inhibitor, for HCN1-DEE using multiple assays, showing efficacy in reducing cation leak and seizures but with side effects.

This paper investigates how epilepsy patients respond to photic stimulation, finding differences in EEG biomarkers that suggest cortical excitability changes associated with seizure states.

The paper classifies molecular defects of six SLC13A5 mutations into two classes, revealing distinct mechanisms of impaired citrate transport and protein folding, with implications for targeted therapies.

This study uses hdEEG to assess excitation/inhibition balance in TLE patients, finding a correlation with cognitive function and gene expression.

The paper identifies differentially expressed proteins in human epileptic brain tissue and validates their roles in epileptogenesis through experimental validation.

This study shows that a low number of mTOR mutant neurons can cause seizures in mice, and similar low levels of mosaicism are found in human patients.

This study shows that chemogenetic activation of parvalbumin interneurons in the piriform cortex reduces seizure frequency and modifies brain connectivity in a mouse model of temporal lobe epilepsy.

This study shows that inducing status epilepticus during zebrafish neurodevelopment increases susceptibility to subsequent seizure-like behavior.

This study identifies depth-dependent cortical microstructure alterations in children with focal epilepsy using quantitative MRI, suggesting potential pre-symptomatic changes detectable regardless of radiological abnormalities.

The paper uses a CRISPRi screen in human iNeurons to identify novel FCD genes that increase mTOR signaling, finding two genes mutated in FCD patient tissue.

This study shows that atenolol reduces cardiac-related mortality in a genetic mouse model of SUDEP by mitigating seizure and LQTS interactions.

This study shows that loss of PV interneurons in the BLA of chronically epileptic mice leads to altered network and behavioral states, contributing to comorbid anxiety and epilepsy.

This study shows gestational exposure to deltamethrin increases susceptibility to post-traumatic epilepsy in offspring and reduces curcumin's antiepileptic effects.

This study outlines the longitudinal epilepsy and developmental trajectories in STXBP1-related disorders using clinical and standardized assessments, revealing subgroup differences and informing future therapeutic strategies.

The paper uses RNA sequencing to analyze transcriptomic changes in mouse neocortical tissue exposed to epileptiform activity, identifying gene expression alterations linked to epilepsy.

This paper evaluates gene therapy using Kv1.1 potassium channel overexpression in a mouse model of FCD, showing reduced seizures but no improvement in cognitive or behavioral issues.