Cervical Cancer and HPV Research

Utilizing a Variant Prioritization Approach to Explore Genetic Variants in Cervical Cancer Cases among Malawian Women

This study identifies genetic variants associated with cervical cancer in Malawian women using whole genome sequencing and variant prioritization.

E2 displacement of CIP2A from TOPBP1 activates the DNA damage response during papillomavirus life cycles

This paper shows E2 activates the DNA damage response by displacing CIP2A from TOPBP1, promoting viral replication and cell proliferation through ATM activation and ATR inhibition.

Multi-scale Transcriptional Characterization of HPV16 and HPV18 in Cervical Cancer: Host Pathway Alterations and Links With Viral Gene Expression Programs

This study compares HPV16 and HPV18 cervical cancers using gene expression data to identify genotype-specific host pathway alterations and viral gene expression programs.

Single-cell analysis identifies TOP2α as a critical regulator of G2/M entry and differentiation-dependent productive HPV replication

The paper identifies TOP2α as a critical regulator of HPV genome amplification during differentiation by analyzing single-cell RNA-seq data from HPV-infected keratinocytes.

HPV16 Utilizes Phospholipase C(s) for its Genome Egress

This study identifies phospholipase C isoforms as mediators of HPV genome egress from transport vesicles after nuclear delivery.

The human papillomavirus L2 protein in the capsid is an ensemble of related structures poised to exit the virus particle

This study uses cryo-EM and computational methods to model the structure of HPV16 L2 protein within the capsid, revealing its conformational flexibility and positioning for virus entry.

Inactivation of the RB1 and PTPN14 tumor suppressors cooperatively enables the lifespan extension activity of the human papillomavirus E7 oncoprotein

This study shows that high-risk HPV E7 proteins require inactivating both RB1 and PTPN14 to extend keratinocyte lifespan, while low-risk E7 needs PTPN14 inactivation alone.

Differentiation-independent Activation of HPV Genome Replication by the lncRNA DINO

This study identifies the lncRNA DINO as a host factor that promotes HPV genome replication and early viral gene expression independently of keratinocyte differentiation.

Allele-specific chromatin modifications of HPV-associated extrachromosomal DNAs in cervical cancer

The paper identifies epigenetic differences between HPV-human hybrid and human-only ecDNAs in cervical cancer, showing allele-specific regulation and enhancer activity in hybrid ecDNAs.

TAOK3 inhibition constrains invasion, potentiates paclitaxel, and reprograms the tumor microenvironment toward anti-tumor immunity in cervical cancer

This study shows TAOK3 inhibition reduces cervical cancer invasion, increases paclitaxel sensitivity, and promotes anti-tumor immunity by altering the tumor microenvironment.

Characterization of the upper epithelial compartment of cervical HSIL

This study characterizes the upper epithelial compartment of cervical HSIL using immunohistochemistry and LCM, revealing distinct compartments with HR-HPV infection and implications for HSIL grading.

High resolution spatial transcriptomics decodes the microenvironmental determinants of response to Nr-CWS therapy in cervical precancerous lesions

This study uses high-resolution spatial transcriptomics to identify microenvironmental differences between responders and non-responders to Nr-CWS therapy in cervical precancerous lesions.

Paracrine Signals from HIV-1 Infected Immune Cells Reprogram Cervical Cancer Pathways

This study shows HIV-1 infected immune cells alter cervical cancer pathways through paracrine signals, with upregulated PI3K-AKT and interferon-stimulated genes.

HPV16 E2 protein possesses intrinsic helicase activity and sterically hinders E1 function through direct interaction

This paper identifies intrinsic ATP-dependent helicase activity in HPV16 E2 protein, identifies key residues for this activity, and shows E2 inhibits E1 helicase through direct interaction.

HPV co-infection burden, vaginal microbiota restructuring, and host context are associated with Cervical precancer risk in a racially restricted observational cohort

The paper assesses how HPV burden, vaginal microbiota, and host factors predict CIN3 risk in a racially diverse cohort, finding that integrated models outperform HPV-only models.

Integrating spatial and single-cell multi-omics analysis of induced pluripotent stem cell-derived cervical adenocarcinoma model

The paper establishes an HPV18-associated cervical adenocarcinoma model using iRCs and integrates spatial transcriptomics with single-cell multi-omics to identify Gland_A as a key component with specific molecular features.

Proteome-anchored multi-omics propagation of recurrent somatic alterations defines tumour states in cervical cancer and enables state-guided drug repurposing

The paper develops a proteome-anchored multi-omics framework to infer tumour states in cervical cancer and identify drug repurposing opportunities based on state-specific proteomic signatures.

The HPV E7 oncoprotein promotes LIM and SH3 Domain Protein 1 (LASP1) transcription via the Rb/E2F1 signalling pathway in HPV-positive cervical cancer cells

This study shows HPV E7 promotes LASP1 transcription through the Rb/E2F1 pathway in cervical cancer cells, adding to previously identified miR-203 regulation.

HPV16 recruitment of SMARCAL1 to viral and host replication forks is required for the viral life cycle

This paper shows that HPV16 requires SMARCAL1 to recruit to viral and host replication forks, which is essential for its life cycle and prevents DNA damage and genome integration.

CKII-Phosphorylated HPV-16 E7 Disrupts Planar Cell Polarity by Recruiting Vangl1

This study identifies Vangl1 as a phosphorylation-dependent interactor of HPV-16 E7, showing that CKII-mediated phosphorylation disrupts planar cell polarity and promotes cervical cancer progression.

The Utility of Fibroblast Co-culture for the Maintenance of Episomes in Human Papillomavirus-Associated Cancer Models

The paper shows that HPV16+ OPC cell lines lose episomal status in monoculture and proposes fibroblast co-culture to maintain episomal viral genomes.

Mus Musculus papillomavirus MmuPV1 resists restriction by human APOBEC3B

This study shows human APOBEC3B does not restrict murine papillomavirus MmuPV1 replication in cellulo or in vivo, suggesting papillomaviruses have evolved mechanisms to evade this antiviral factor.

The magnitude and durability of neutralizing antibody responses to human papillomavirus vaccine do not depend on DNA sensing pathways

This study shows that neutralizing antibody responses to the 9-valent HPV vaccine are not influenced by DNA sensing pathways.

Differentiation-Dependent Proximity Proteomics Identifies Novel Host Factors Linked to HPV16 E2 Function

This study identifies novel host factors interacting with HPV16 E2 during differentiation using proximity proteomics, revealing a cooperative E2-TOPBP1-NCL axis critical for viral genome stability.

HPVarcall: Calling lineages and sublineages for partial DNA sequences of human papillomavirus

HPVarcall assigns HPV variant sequences to lineages and sublineages using statistical models trained on sublineage-specific genomic alignments, achieving high accuracy for sequences of 1000 nucleotides or longer.

Spatial analysis of HPV associated cervical intraepithelial neoplastic tissues demonstrate distinct immune signatures associated with cervical cancer progression

The paper analyzes spatial immune signatures in HPV-associated cervical tissues to identify immune modulation patterns linked to cancer progression.

Topoisomerase IIα orchestrates secretion of IL-6 and IL-8 with human papillomavirus replication

This paper shows Top2 promotes HPV replication by inducing IL-6 and IL-8 secretion through TLR4, independent of DDR.

HPV16 E6 oncoprotein promotes microhomology-mediated viral integration by upregulating POLQ expression

This study shows HPV16 E6 oncoprotein increases POLQ levels via UBE3A and RAD23A regulation, enhancing MMEJ to promote viral integration and oncogenesis.

A Mass Spectrometry-Based Interactome Study on Anisomelic Acid and Its Effects on HPV16 E7

This study investigates anisomelic acid's effect on HPV16 E7 degradation using CETSA and mass spectrometry, revealing its interaction with E3 ubiquitin ligases and chaperone complexes.

TvAP65 in Trichomonas vaginalis Promotes HPV Infection by Interacting with Host Molecules

This study shows that TvAP65 in Trichomonas vaginalis enhances HPV infection by upregulating CD151 and HSPG2, with SPCS1 playing a key role in this process.