Cell death mechanisms and regulation

The paper identifies a lipid signature associated with BAK-driven apoptotic pore formation and shows cholesterol inhibits pore formation by preventing BAK clustering.

This study uses computational methods to analyze Zn2+-mediated non-competitive inhibition of caspase-3, revealing atomic-level insights into its mechanism and potential therapeutic applications.

The paper identifies CAD-bound genes involved in both muscle cell differentiation and cancer-causing translocations, showing CAD-induced breaks are physiologic in differentiation and linked to oncogenic gene regulation.

This study investigates the evolution of apoptotic signalling pathways in lophotrochozoans, revealing diversification and loss of key components across different groups.

This paper identifies paraptosomes as a novel morphological feature of paraptotic cell death, showing they originate from the Golgi apparatus and are not induced by isolated stressors.

This study identifies WSB2 as a regulator of mitochondrial apoptosis and shows that targeting the WSB2-NOXA axis enhances sensitivity to BCL-2 inhibitors in cancer cells.

This study identifies RIPK4 as a driver of chemotherapy resistance in CRC through TP53 mutations, enhancing MTHFD1 phosphorylation and NADPH production to reduce ROS and promote metastasis.

This study identifies a novel interaction between BOK and BCL-2 transmembrane domains that regulates apoptosis and suggests it as a potential drug target.

This study investigates Bax membrane insertion in nanodiscs, showing Tom22-dependent multi-step processes involving hydrophobic motifs and conformational changes.

This study investigates how caspase-8 regulates TNFα production and restricts Coxiella burnetii replication in macrophages during infection.

This study shows that platelets induce cardiac cell apoptosis via FasL after acute myocardial infarction, contributing to cardiac damage and dysfunction.

This paper introduces a method to induce cell death in Drosophila using Ronidazole and Nitroreductase with spatial and temporal control via GAL4/UAS and diet feeding.

This study identifies key residues in the BAK:VDAC2 interaction, showing that disrupting this interaction can inhibit or promote apoptosis depending on the context.

This study identifies a non-apoptotic role of EGL-1 in promoting exopher production and supporting neuronal health in C. elegans.

This study shows that SARM1 TIR domains produce minor amounts of glycocyclic ADPR molecules in vitro and in bacterial cells, suggesting a potential role in axonal death.

This study shows that expressing caspase-resistant ROCK1 in B cell lymphoma mice prolongs survival by reducing cell numbers and creating a proliferation-suppressive bone marrow microenvironment.

The paper compiles a comprehensive database of cell death regulators by curating existing resources and UniProt/Gene Ontology entries, providing a manually curated resource with associated code.

The paper uses single-molecule co-immunoprecipitation to profile BCL2 interactions with BH3-only proteins, revealing how mutations affect ABT-199 resistance through quantitative PPI data.

The paper designs and characterizes non-hydrolyzable peptidomimetic inhibitors to selectively probe caspase-7 over caspase-3 by exploiting differences in their prime-side active-site architecture.

This study shows SMAC mimetics overcome apoptotic resistance in ovarian cancer by targeting the MSLN-TNF alpha axis, enhancing cell death and synergizing with chemotherapy.

This study identifies the CNH domain of NRK as a key mediator of cell death by localizing to the plasma membrane via phospholipid binding.

This study shows that PINK1 and BNIP3 have opposing effects on Rbf1-induced apoptosis in Drosophila, with PINK1 promoting and BNIP3 protecting against apoptosis.

This study shows that Wengen (Wgn) promotes cell survival by activating the p38 MAP kinase pathway through dTRAF1 in response to ROS generated during apoptosis, distinct from Grindelwald (Grnd).

The paper shows that cell size predicts physiological germ cell death in C. elegans, regulated by actomyosin contractility at apical rachis bridges.

This study uses a yeast system to investigate the role of human ECE-1 isoforms in apoptosis and their potential involvement in congenital heart disease.

This study uses computational systems biology to predict DLBCL cell response to BH3-mimetics by modeling molecular variability and genetic lesions.

The paper identifies P53 and its targets PUMA and NOXA as regulators of competitive fitness in pluripotent cells through mitochondrial regulation.

This study uses hydrogen deuterium exchange mass spectrometry to show that Mcl-1's binding specificity arises from dynamic modes in its unbound state, distinct from Bcl-2.

This study shows non-apoptotic caspase activation modulates Hedgehog-signalling and autophagy in ovarian somatic stem cells, sustaining their function without inducing apoptosis.

The paper presents cryo-EM structures of BIRC6-client complexes to elucidate the mechanism of Smac-mediated caspase release and BIRC6 function in apoptosis regulation.