Cell death mechanisms and regulation

MCL1 may not mediate chemoresistance

This study challenges the role of MCL1 in chemoresistance by showing no evidence of nuclear accumulation or DNA repair interactions in live cancer cells.

Response to SMAC mimetics in patient-derived models of triple-negative breast cancer relies on RIPK1 activation

This study identifies RIPK1 activation as a key determinant of response to SMAC mimetics in TNBC, showing that resistance is linked to impaired RIPK1 autophosphorylation and HOIP overexpression.

Oxidized TRX1 and DPP8/9 stabilize the MIA40-AIFM1 complex during intrinsic apoptosis

The paper shows that oxidized TRX1 and DPP8/9 stabilize the MIA40-AIFM1 complex during intrinsic apoptosis, promoting NLRP1 restraint and preventing pyroptosis.

Low-order MLKL oligomers induce irregular membrane defects in necroptosis

This study shows that low-order MLKL oligomers cause irregular membrane defects during necroptosis, disrupting plasma membrane integrity without forming defined pores.

Bruce suppresses autophagy-regulated caspase activity and wing tissue growth in Drosophila

The paper shows that Bruce, an autophagy-regulated inhibitor, suppresses Dcp-1 activity and wing tissue growth in Drosophila, independent of apoptotic pathways.

The Smac mimetic drug Xevinapant sensitizes triple negative breast cancer to radiotherapy-induced cell death in a TNFα dependent manner

This study shows Xevinapant enhances radiotherapy-induced cell death in TNBC cells, with TNFα playing a key role in this effect.

The Mitochondrial Ubiquitin Ligase MARCHF5 Cooperates with MCL1 to Inhibit Apoptosis in KSHV-Transformed Primary Effusion Lymphoma Cell Lines

This study identifies a genetic interaction between MCL1 and MARCHF5 in PEL cells, showing that MARCHF5 promotes cell survival by degrading NOXA, an antagonist of MCL1.

Structural mechanism of Gasdermin E-mediated mtDNA release from apoptotic mitochondria

This study identifies GSDME-N as a mediator of mitochondrial inner membrane permeabilization and mtDNA release during apoptosis, revealing its structural mechanism and impact on inflammatory responses.

Mitochondrial priming in human germ cell tumors is dependent on MCL1 and BCL2L1

This study identifies MCL1 and BCL2L1 as critical for GCT survival and shows their inhibition enhances response to DNA damaging agents.

Starvation improves epithelial fitness by selectively extruding DNA damaged cells

The paper shows that starvation-induced cell extrusion selectively removes DNA-damaged cells, improving tissue fitness through a p53-dependent pathway.

Positive and negative effects of CaMCA1 deletion on stress sensitivity and virulence

The paper examines how deletion of CaMCA1 affects stress sensitivity and virulence in C. albicans, showing context-dependent dual roles of Mca1p.

Characterization of a maintainable human myeloid model of VEXAS syndrome with enhanced TNF-induced cell death and DAMP release

This study creates a human myeloid cell model of VEXAS syndrome with UBA1 mutations, showing increased TNF-induced cell death and DAMP release.

High-throughput spheroid profiling reveals BMP-driven rewiring of glioma cell death responses

This study uses high-throughput spheroid profiling to show BMP2 and BMP4 rewire glioma cell death responses by suppressing standard therapies and priming for lipid-dependent necrosis.

BCL-XL Dependence is a Subtype Agnostic Actionable Feature of Difficult-to-Treat Kidney Cancers

The paper identifies BCL-XL dependence as a common vulnerability in various kidney cancer subtypes and develops a model to predict it using biomarkers like AMPK activation.

Engineered caspases directly rewire mutant Ras to cell death

This paper engineers caspases to selectively kill cells with mutant Ras by reconstituting active complexes upon detection, showing potent in vitro efficacy against cancer lines.

Mitotic catastrophe and other cellular instability events in sodium valproate-treated HeLa cells

This study examines how sodium valproate induces mitotic catastrophe in HeLa cells, showing increased caspase-2 and p53 activity without changes in DNMT1/DNMT3B levels.

A whole-genome screen identifies a bilateral Flower-Grindelwald/TNFR-Veli/LIN-7 communication module in cell competition

The paper identifies a bilateral communication module involving Fwe, Grindelwald/TNFR, and Veli/LIN-7 that mediates cell competition in Drosophila.

Production of membrane-embedded Bcl-2 proteins - Use of cell-free synthesis in continuous exchange for co-translational insertion of Bcl-2 proteins in lipid bilayer nanodiscs

This paper describes methods to produce membrane-embedded Bcl-2 family proteins using cell-free synthesis in lipid bilayer nanodiscs for structural and functional studies.

FLIP is essential for oncogenic KRAS-driven lung cancer

This study identifies FLIP as a critical survival factor in KRAS-mutant lung cancers, revealing a KRAS-ERK-FLIP axis that protects against apoptosis and suggests FLIP as a therapeutic target.

Peptide tiling across viral proteomes identifies modular regulators of stress-induced cell death

The paper uses peptide tiling to identify viral protein regions that modulate stress-induced cell death in U2OS cells, revealing modular regulatory functions.

How specific structural differences of Bcl2 proteins modulate the interaction with BH3 domains and apoptotic function

The paper investigates how structural differences in Bcl2 proteins affect BH3 domain interactions and apoptotic function using simulations and experimental validation.

VDAC2 stabilizes a membrane-inserted, primed intermediate of BAX activation

This study identifies VDAC2 as a regulator of BAX activation by stabilizing a primed, membrane-inserted intermediate in the BAX activation pathway.

Necroptotic Signalling Diverts Keratinocyte Fate to Promote Differentiation and Slow Wound Healing

This study shows that necroptosis in keratinocytes promotes differentiation and slows wound healing by preserving barrier integrity, suggesting it can be modulated to enhance tissue repair.

The Fas-FADD-caspase-8 axis is a cancer cell-intrinsic determinant of cytotoxic lymphocyte-mediated killing

This study identifies the Fas-FADD-caspase-8 axis as a critical determinant of cancer cell susceptibility to cytotoxic lymphocyte killing, independent of executioner caspases.

Partitioning of nuclear material into apoptotic fragments through establishment of asymmetric cell death morphology

This study identifies a new apoptotic morphology, AsyCDM, where apoptotic cells asymmetrically partition nuclear material into apoptotic bodies via ROCK1-dependent actomyosin contraction.

Lipid droplets sequester cell death effectors and delay regulated cell death execution

The paper shows lipid droplets delay regulated cell death by sequestering mitochondrial effectors like Bax, thereby reducing apoptosis execution in cancer and germ cells.

A peptide-based screen for cell death inhibitors identifies the cytoprotective compound CDL36

The paper identifies CDL36, a compound that inhibits cell death by preventing mitochondrial outer membrane permeabilization, with potent cytoprotection against doxorubicin-induced toxicity.

A non-lytic membrane permeabilization program drives epithelial cell turnover in vivo

The paper identifies a non-lytic membrane permeabilization program in Drosophila enterocytes that enables cell turnover without compromising tissue architecture.

Pre-existing levels of pro-survival proteins and induction of BCL-XL dictate cell fate after p53 activation

The paper shows that pre-existing levels of pro-survival proteins and BCL-XL induction determine cell fate after p53 activation, with implications for cancer therapy.

The combination of nelfinavir and cisplatin drives lytic cell death through a caspase-8/caspase-3/GSDME axis in platinum-resistant ovarian cancer cells