Circadian rhythm and melatonin

MOSAIC improves circadian rhythm detection in proteomic data by integrating transcriptomic information, outperforming existing methods and revealing non-circadian trends.

This study uses mathematical models to show that coupling transcriptional and post-translational controls via feed-forward loops improves circadian oscillator robustness against basal leakage.

This study identifies the circadian clock mechanism in mammals that drives seasonal responses to photoperiod changes through BMAL2 and EYA3/TSH pathways.

The paper develops a 12-gene circadian biomarker from epidermal samples that accurately estimates circadian phase across body sites, ages, sexes, and platforms.

This study experimentally shows that Per2AS regulates circadian clock amplitude through a negative feedback loop with Per2, without producing a protein.

The paper investigates temperature compensation in Drosophila circadian clocks, showing that peripheral oscillators overcompensate temperature changes unlike central brain clocks.

TimeTrial evaluates cycle detection algorithms in circadian transcriptomics by analyzing real and synthetic data to optimize experimental design and analysis choices.

The paper characterizes a gene expression oscillator in C. elegans larvae, showing it starts in embryos, arrests transiently, and ceases in adults, operating near a SNIC bifurcation.

This study identifies nitric oxide as a critical signaling molecule linking circadian pacemaker neurons to locomotor behavior in Drosophila, with glia as a major source of NO.

The paper investigates how different components of photoperiodic light influence circadian clock properties through behavioral and SCN measurements.

The paper evaluates seven circadian rhythm detection algorithms using empirical datasets and simulations, providing guidelines for selecting methods based on data characteristics.

The paper shows that a slow visual phototransduction pathway contributes to circadian clock synchronization in Drosophila without requiring Cryptochrome.

This study shows that partial loss of Rev-erb in mice leads to improved metabolic traits compared to wildtype and knockout mice.

This paper introduces a penalized machine learning method to analyze circadian rhythms from wearable device data and links daily rhythms to motor development in infants.

This study assesses whether circadian rhythms in brain-injured patients can be accurately measured using actigraphy after correcting for passive movements.

This study identifies CBS-CRY1 binding as a regulatory mechanism linking circadian rhythms and metabolism, showing that CBS modulates CRY1 activity and vice versa.

This study shows that structural plasticity in circadian clock neurons is crucial for integrating sensory inputs, not for maintaining circadian timekeeping.

This study shows that mutating a PER2 phosphodegron in mice leads to longer circadian periods and altered molecular stability.

The paper develops conceptual models of circadian entrainment using global optimization to explain phenotypic features like phase response curves and seasonal variability.

This paper uses mathematical modeling to show that rhythmic deadenylation is the main driver of poly(A) tail length rhythms and mRNA translatability in circadian gene expression.

The paper analyzes BHLHE41 coding sequences across 27 mammals, finding strong purifying selection and unexpected indels in the gorilla sequence that may indicate an annotation error.

The paper identifies a repressive domain in CHRONO that interacts with BMAL1 to repress circadian transcription, differentiating its function from PER.

The paper demonstrates that FlyBox, a tracking system originally for Drosophila, can effectively measure locomotor activity in Anopheles and Aedes mosquitoes over multiple days under different light conditions.

This study evaluates seven methods for detecting rhythmic gene expression and finds they are only consistent for genes with strong rhythmic signals.

The paper uses single-cell in vivo imaging to show light-initiated circadian oscillators in zebrafish, revealing that light exposure initializes cellular clocks during development.

This study examines the presence and functional role of zinc in the circadian system, finding zinc in key areas but no significant effect on circadian responses.

The paper shows that minimal clock models can reproduce essential circadian phenotypes like fast jetlag and seasonal shifts through amplitude effects and twist mechanisms.

The paper shows JETLAG and the DYSCHRONIC-SLOWPOKE complex antagonistically regulate circadian output and synaptic development in Drosophila.

The paper compares photoperiodic responses in gonadal and somatic growth between two vole species, finding species-specific differences in sensitivity and developmental programming of the photoperiodic neuroendocrine system.