Circadian rhythm and melatonin

This study shows that dietary methionine/choline deficiency disrupts circadian rhythms and gene expression in mice, with effects dependent on circadian time.

This study shows that intrinsic skeletal muscle function and contraction-stimulated glucose uptake in mice do not vary across the 24-hour circadian cycle.

This study shows metadichol increases expression of CRY1, CLOCK, and PPARGC1A in human fibroblasts, but not PER1 or BMAL1, suggesting indirect effects on circadian clock genes.

This study compares seven algorithms for detecting differential rhythmicity in transcriptomic data, finding high overlap in results but differences in output numbers and parameters.

This paper extends a biochemical model of circadian rhythms to include mechanical effects, showing that mechanical signals must be within an optimal range for oscillations to occur.

This study shows that light suppresses melatonin differently in young and older adults, with young adults relying solely on melanopsin and older adults involving L-cones as well.

This paper introduces a model to distinguish between endogenous and exogenous factors affecting sleep timing using longitudinal data and personalized mathematical modeling.

This study investigates the impact of blue-yellow light changes on the human circadian clock and sleep, finding no significant effects under moderate light levels.

The paper shows that endogenous circadian clock proteins form dynamic microbodies distinct from phase separation condensates, suggesting an enzyme-like mechanism in the circadian feedback loop.

LimoRhyde2 analyzes genomic data to identify rhythmic genes by focusing on effect sizes rather than statistical significance, revealing genes with high-amplitude rhythms.

This study identifies TARANIS as a novel regulator of the Drosophila circadian clock by enhancing the transcriptional activity of VRILLE and PDP1.

This study shows that P2-HNF4 regulates ketogenesis in the liver and is involved in circadian metabolism, with implications for gender-specific ketone body levels.

The paper investigates the timing mismatch between somatic Ca2+ activity and neuropeptide release in Drosophila sLNv neurons, finding that terminal Ca2+ spiking and neuropeptide release peak midmorning, hours before their behavioral effects.

This study examines how diabetes affects the daily rhythmic gene expression in retinas, finding phase shifts in the transcriptional cycle linked to metabolic and hypoxia pathways.

This study examines how different light levels affect task-evoked pupil responses during cognitive tasks, finding that higher light levels increase pupil dilation in response to auditory stimuli.

This study shows that methamphetamine exposure in mice induces infradian locomotor rhythms and mania-like behaviors, which depend on dopamine neurons projecting to the nucleus accumbens.

This study examines how lithium affects honey bee locomotor activity and circadian rhythms, finding that it alters activity levels and disrupts circadian patterns, similar to its effects in bipolar disorder treatment.

This study resolves conflicting models of melanopsin phototransduction in ipRGC subtypes, showing HCN channels are dispensable in M4 and M2, with TRPC and T-type calcium channels playing key roles.

This study shows that SCN neurons maintain circadian rhythms at moderate hypothermia but suspend them at deep hypothermia, with Ca2+ rhythms resetting faster than transcriptional rhythms upon rewarming.

The paper investigates how repeated short light exposures affect sustained pupil responses during different cognitive tasks, finding that higher melanopic irradiance increases pupil responses and that task context influences variability.

This study uses isotope tracing to show rhythmic glucose metabolism in Drosophila, revealing internal mechanisms controlling metabolic homeostasis across day and night.

This study shows that the Drosophila circadian gene cycle (cyc) has a non-circadian role in the development of clock neurons, affecting fasciculation and morphology.

The paper analyzes bulk RNA sequencing data from Drosophila fat bodies under different temperatures to show temperature-dependent circadian transcriptome changes and gene coordination.

The paper identifies genetic variants and expression changes in circadian genes and BDNF associated with post-stroke cognitive impairment in Eastern Indians.

This study examines the spatio-temporal dynamics of nuclear CREB1 in rat pinealocytes, finding that its distribution varies across time and cell types, with increased dispersion at night.

This paper introduces ODeGP, a Gaussian Process-based method for detecting oscillations in time series, and shows it outperforms existing methods in detecting weak and non-stationary rhythms in qPCR data.

CIRCUST reconstructs temporal order of molecular rhythms from single timepoint data, validated on controlled experiments and applied to GTEx tissues to build a human daily rhythm gene expression atlas.

The paper investigates circadian rhythms in Synechocystis PCC 6803 under continuous light, finding self-sustained 24-hour oscillations without light-dark cycles.

This study shows prolonged light exposure at specific times affects circadian period in Drosophila, with blue- and UV-blocked light lengthening the period through multiple photoreceptors.

The paper identifies a brain circuit and mechanism in mice that enables adaptation to changes in daylength by reorganizing neurotransmitter deployment in specific neurons.